FGF-16 human

Description

• General description: Fibroblast growth factor-16 (FGF-16) is a heparin binding growth factor that is a member of the FGF9 subfamily.[1] Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation.[2] Recombinant human FGF-16 is a 23.7 kDa protein consisting of 207 amino acid residues.
• Biochem/physiol Actions: Fibroblast growth factor-16 (FGF-16) signals through FGFR 2c and 3c. FGF-16 plays a role in the development of the central nervous system. This protein has a positive effect on mitosis and cell survival. FGF-16 also has roles in tissue repair, embryonic development, morphogenesis and tumor growth.[2]
• Sequence: MAEVGGVFAS LDWDLHGFSS SLGNVPLADS PGFLNERLGQ IEGKLQRGSP TDFAHLKGIL RRRQLYCRTG FHLEIFPNGT VHGTRHDHSR FGILEFISLA VGLISIRGVD SGLYLGMNER GELYGSKKLT RECVFREQFE ENWYNTYAST LYKHSDSERQ YYVALNKDGS PREGYRTKRH QKFTHFLPRP VDPSKLPSMS RDLFHYR
• Physical form: Lyophilized from 5 mM sodium phosphate, pH 9.0, containing 0.1 M L-arginine and 0.4 mM DTT.
• Reconstitution: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.5-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.