Fmoc-D-Dpr(ivDde)-OH

Description

• General description: This orthogonally-protected derivative is based on the hindered Dde variant ivDde. It has very similar chemical properties to Fmoc-Lys(Dde)-OH, except that the side-chain ivDde group is considerably more stable to piperidine than Dde, and is less prone to migrate from protected to unprotected lysine side-chains. When removing ivDde in the presence of allyl based protecting groups, allyl alcohol should be included in the deprotection solution to prevent reduction of the allyl group. Associated Protocols and Technical Articles Cleavage and Deprotection Protocols for Fmoc SPPS Guide to Selection of Orthogonally-Protected Building Blocks for Fmoc SPPS
• Linkage: Replaces: 04-13-1074
• Analysis Note: Color (visual): white to slight yellow to beigeAppearance of substance (visual): powderIdentity (IR): passes testEnantiomeric purity: ≥ 99.0 % (a/a)Purity (TLC(157A)): ≥ 98 %Purity (TLC(CMA2)): ≥ 98 %Assay (HPLC, area%): ≥ 95.0 % (a/a)Water (K. F.): ≤ 1.0 %Assay (acidimetric): ≥ 90.0 %To see the solvent systems used for TLC of Novabiochem® products please click here.
• Legal Information: Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany