Fmoc-Ser(tBu)-(Dmb)Gly-OH

Description

• General description: Fmoc-Aaa-(Dmb)Gly-OH dipeptides offer the same benefits as pseudoproline dipeptides such as prevention of aggregation and improvements in product quality but for peptide sequences containing Gly. They are extremely easy to use. Standard coupling methods like PyBOP®/DIPEA or DIPCDI/HOBt can be used for their introduction. Removal of the Dmb group and regeneration of the glycine residue occurs during the course of standard TFA-mediated cleavage reaction. Associated Protocols and Technical Articles Cleavage and Deprotection Protocols for Fmoc SPPS Overcoming Aspartimide Formation in Fmoc SPPS
• Analysis Note: Colour (visual): white to off whiteAppearance of substance (visual): powderIdentity (IR): passes testOptical rotation α 25/D (c=1 in methanol): -26.0 - -22.0 °Purity (TLC(157A)): ≥ 98 %Assay (HPLC, area%): ≥ 97.0 % (a/a)Solubility (1 mole in 2 ml DMF): clearly solubleAssay (acidimetric): ≥ 90.0 %Water (K. F.): ≤ 1.00 %Ethyl acetate (HS-GC): ≤ 0.5 %Acetate (IC): ≤ 0.02 %To see the solvent systems used for TLC of Novabiochem® products please click here.
• Legal Information: Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany