Rink Amide resin (100-200 mesh)

Description

• General description: An excellent support for the Fmoc SPPS of peptide amides. This resin is more acid-sensitive than Rink Amide AM and Rink Amide MBHA resins. Cleavage with high concentrations of TFA can lead to the breakdown of the linker, with the concomitant formation of by-products that can not be removed by simple washes. These problems appear to be minimized through the use of low TFA concentrations or by the addition of trialkyl silanes to the cleavage mixture. Associated Protocols and Technical Articles Protocols for Loading of Peptide Synthesis Resins
• Linkage: Replaces: 01-64-0013
• Analysis Note: Color (visual): white to pale yellow to beigeAppearance of substance (visual): beadsLoading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.40 - 0.80 mmol/gTNBS-Test: passes testSwelling Volume (in DMF): lot specific resultSwelling Volume (in CH₂Cl₂): lot specific resultTotal swelling volume acc. Houben Weyl (in CH2Cl2): ≥ 5.2 ml/gTotal swelling volume acc. Houben Weyl (in DMF): ≥ 5.2 ml/gThe polymer matrix is copoly (styrene-1 % DVB) 100 - 200 mesh.
• Legal Information: Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany