Rink Amide AM resin (200-400 mesh)

Description

• General description: This support comprises the modified Rink amide linker attached via norleucine to aminomethylpolystyrene, and is an ideal tool for the Fmoc SPPS of peptide amides. Cleavage from this resin can be effected by a single step treatment with 95% TFA, providing peptide amides in high yields and purities.Associated Protocols and Technical Articles Protocols for Loading of Peptide Synthesis Resins
• Application: Second generation amphiphilic poly-lysine dendrons inhibit glioblastoma cell proliferation without toxicity for neurons or astrocytes: Uses Rink Amide AM resin with a 0.71mmol/g loading capacity for synthesizing amphiphilic dendritic amides. (Janiszewska et al., 2016). The Role of Phosphoglycans in the Susceptibility of Leishmania mexicana to the Temporin Family of Anti-Microbial Peptides: Describes peptide synthesis on Rink Amide AM resin with a 0.79 mmol/g loading capacity. (Eggimann et al., 2015).
• Linkage: Replaces: 01-64-0038
• Analysis Note: Colour (visual): white to yellow to beigeAppearance of substance (visual): beadsLoading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.40 - 0.80 mmol/gTNBS-Test: passes testSwelling Volume (in DMF): lot specific resultSwelling Volume (in CH₂Cl₂): lot specific resultTotal swelling volume acc. Houben Weyl (in CH2Cl2): ≥ 5.2 ml/gTotal swelling volume acc. Houben Weyl (in DMF): ≥ 5.1 ml/gIdentity (of the substitution): passes testThe polymer matrix is copoly (styrene-1 % DVB), 200 -400 mesh.
• Legal Information: Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany