Aminomethyl NovaGel

Description

• General description: Aminomethyl NovaGel is a PEG-PS resin which has been designed to meet the requirements of organic chemists for resins of high substitution coupled with broad solvent compatibility. This support has a nominal loading of 0.7 mmole/g – almost twice that of comparable resins – but still retains most of the swelling characteristics of conventional PEG-PS supports. It is prepared from a special high-swell version of AM resin by partial derivatization with methyl-PEG-p-nitrophenylcarbonate [1]. Resin functionality is provided by residual aminomethyl groups. The urethane linkage between the PEG and the base resin is stable to strongly acidic, basic and reducing conditions, ensuring minimal loss of PEG chains during synthesis. Furthermore, because the linker is not attached to the end of the PEG chains, if leaching of PEG does occur, the product is not contaminated with U.V. absorbing linker-PEG fragments which can complicate the nmr spectra and HPLC profiles of products obtained with other PEG-PS supports. Associated Protocols and Technical Articles Protocols for Loading of Peptide Synthesis Resins Literature references[1] J. H. Adams, et al. (1998) J. Org. Chem., 63, 3706.
• Linkage: Replaces: 01-64-0283
• Analysis Note: Color (visual): white to yellow to beigeAppearance of substance (visual): beadsLoading (determined from the substitution of the Fmoc-Leu loaded resin): 0.60 - 0.90 mmol/gTNBS-Test: passes testSwelling Volume (in DMF): lot specific resultThe PEG-PS resin is prepared from aminomethyl copoly (Styrene 1% DVB), 100 - 200 mesh.
• Legal Information: Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany