NovaSyn®TG Sieber resin

Description

• General description: NovaSyn TG Sieber resin consists of 130 μm NovaSyn TG bromo resin derivatized with Sieber′s xanhydrylamine linker [1,2]. This resin is ideal for the Fmoc SPPS of partially protected peptide amide fragments. Cleavage from this support is effected by treatment with 1% TFA in DCM, conditions that leave most standard side-chain protecting groups intact. This resin can be reductively alkylated and used to prepare secondary carboxamides [3]. It can also be employed to produce protected peptide fragments in which the C-terminal carboxylic acid group is blocked as a hydroxymethylphenoxy-β-alaninamide ester [4].Associated Protocols and Technical Articles Protocols for Loading of Peptide Synthesis ResinsLiterature references [1] P. Sieber (1987) Tetrahedron Lett., 28, 2107.[2] C. Somlai, et al. in ′Peptides 1992, Proc.22nd European Peptide Symposium′, C. H. Schneider & A. N. Eberle (Eds), ESCOM, Leiden, 1993, pp. 198. [3] W. C. Chan, et al. (1995) J. Chem. Soc., Chem. Commun., 1475. [4] W. C. Chan, et al. (1995) J. Chem. Soc., Chem. Commun., 589.
• Linkage: Replaces: 01-64-0092
• Analysis Note: Color (visual): light yellow to yellow to beigeAppearance of substance (visual): beadsLoading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.10 - 0.25 mmol/gSwelling Volume (in DMF): lot specific resultThe polymer matrix is NovaSyn TG resin (130µm)
• Legal Information: NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany