2-(4-Bromomethylphenoxy)ethyl polystyrene HL

Description

• General description: This versatile support is an excellent tool for the solid phase immobilization of carboxylic acids, amines and alcohols. Acids are attached by treating the resin with the appropriate DIPEA salt in DMF in the presence of CsI [1,2]. Reaction with aryl and alkyl amines provides resin-bound secondary amines. These can be readily acylated to give sulfonamides or anilides that can be cleaved with 95% TFA. Since this resin does not contain a benzylic ether linkage, it gives cleaner products than similar supports derived from Wang resin, free from impurities arising from breakdown of the linker. For examples using a similar resin, please see [1,2,3,4]. Associated Protocols and Technical Articles Protocols for Loading of Peptide Synthesis Resins Literature references [1] J. W. Corbett, et al. (1997) Bioorg. Med. Chem. Lett., 7,1371. [2] G. A. Morales, et al. (1998) J. Org. Chem., 63,1172. [3] K. Ngu & D. V. Patel (1997) Tetrahedron Lett., 38, 973.[4] B. Raju & T. P. Kogan (1997) Tetrahedron Lett., 38, 4965.
• Linkage: Replaces: 01-64-0400
• Analysis Note: Color (visual): white to yellow to beigeAppearance of substance (visual): beadsSwelling Volume (in DMF): lot specific resultLoading (determined by elemntal analysis of bromine): 0.80 - 1.30 mmol/gThe polymer matrix is copoly (styrene - 1 % DVB), 100 - 200 mesh
• Legal Information: Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany