Fmoc-Gly-Wang resin (100-200 mesh)

Description

• General description: Pre-loaded resin for synthesis of peptide acids containing a C-terminal glycine amino-acid residue by Fmoc SPPS. This pre-loaded Wang resin is prepared using a synthesis-tested base resin, to ensure reproducibility and efficacy in SPPS. Loading of the Fmoc-amino acid is carried out under conditions to minimize enantiomerization and dipeptide formation, the values of which are provided on the COA. The lot number of the batch of Fmoc-amino acid used to prepare the resin is also provided on the COA, to provide transparency and traceability. Associated Protocols and Technical Articles Cleavage and Deprotection Protocols for Fmoc SPPS
• Application: Tacrolimus research solution in transplant rejection: Tacrolimus is evaluated for its effectiveness in preventing acute rejection rates in vascularized composite allografts, highlighting its critical role in transplant medicine and immunosuppressive therapy (Van Dieren et al., 2024).Calcineurin inhibitor assay development: Studies involving tacrolimus focus on optimizing formulations using nanostructured lipid carriers, demonstrating its application in enhancing the bioavailability and therapeutic efficacy of this potent calcineurin inhibitor (Rios et al., 2024).
• Linkage: Replaces: 04-12-2053
• Analysis Note: Color (visual): white to yellow to beigeAppearance of substance (visual): beadsLoading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.40 - 1.00 mmol/gSwelling Volume (in DMF): lot specific resultIdentity (of the substitution): passes testContent Dipeptide (HPLC): ≤ 0.50 % (a/a)Novabiochem Fmoc amino acid: lot numberThe qualitiy of this resin has been confirmed by the successful synthesis of the 21mer peptide related to myelin oligodendrocyte glycoprotein (35-55), with an Fmoc-Val-Wang resin made from the same batch of base resin.The polymer matrix is copoly (styrene - 1% DVB), 100 - 200 mesh.
• Legal Information: Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany