H-Pro-2-ClTrt resin

Description

• General description: Pre-loaded resin for synthesis of protected peptide acids containing a C-terminal proline amino-acid residue by Fmoc SPPS. Cleavage of the protected peptide is effected by treatment with 1% TFA in DCM or 20% TFE in DCM. The use of this resin enables the synthesis of peptides containing C-terminal Pro without risk of diketopiperazine formation. Associated Protocols and Technical Articles Cleavage and Deprotection Protocols for Fmoc SPPS
• Application: B Yakimova et al. Reported the use of H-Pro-2-ClTrt resin in the synthesis of short peptides with potential ACE inhibitory activity (B Yakimova, et al., 2021).S Wang et al. Detailed the use of H-Pro-2-ClTrt resin in a study on aminoacyl chain translocation catalysed by a type II thioesterase domain in an unusual non-ribosomal peptide synthetase (S Wang, et al., 2022).LP Vu et al. Described the use of H-Pro-2-ClTrt resin in the synthesis of inhibitors for serine proteases (LP Vu, et al., 2022).
• Linkage: Replaces: 04-12-2805
• Analysis Note: Color (visual): pale yellow to beigeAppearance of substance (visual): beadsIdentity (of the substitution): passes testLoading (determined from the substitution of the Fmoc-Leu loaded resin): 0.30 - 1.10 mmol/gSwelling Volume (in DMF): lot specific valueThe polymer matrix is copoly (styrene - 1% DVB) 200 -400 mesh
• Legal Information: Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany