Description

• General description: Native α1-acid glycoprotein from human plasma. Glycoprotein used for the study of the structure of oligosaccharide units. Consists of 40 - 45% carbohydrate. Present in human plasma at concentrations of 55 - 140 mg/100 ml. Clinically,α1-AG is an acute-phase reactant that, together with haptoglobin, indicates acute inflammation. Selectively suppresses the augmentation of NK cell activity by IFN-α and IFN-γ. Theα1-AG:α1-antitrypsin ratio is useful in diagnosis of liver disease. A sialic acid-deficientα1-AG has been observed in serum or urine of patients with Hodgkin’s disease, psoriatic arthritis, diabetes, and chronic myeloid leukemia. Sialic acid-deficientα1-AG has an affinity for vitamin B12.
• Warning: Toxicity: Standard Handling (A)
• Preparation Note: Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
• Reconstitution: Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for to 3 months at (-20°C).
• Other Notes: Aso, H., et al. 1999. Inflammation 23, 117.Schmid, K., et al. 1973. Biochemistry 12, 2711.
• Legal Information: CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
• Disclaimer: RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.