Ganglioside GD1a, Disialo, Diammonium Salt, Bovine Brain

Description

• General description: Disialoganglioside prepared from bovine gray matter. Useful as a differentiation marker of tumor cell growth. Protein kinase C inhibitor. Readily converted to GM1 by bacterial and mammalian sialidases without detergent or bile salts. One mole yields 2 moles of sialic acid by thiobarbituric acid assay. The molecular weight is based on stearoyl-18:0.Note: This product is not to be used for animal treatment, in vivo research, or in any other contact procedure with livestock.
• Biochem/physiol Actions: Cell permeable: no
• Warning: Toxicity: Irritant (B)
• Preparation Note: For use in aqueous systems, dissolve in a small amount of DMSO and then sonicate in buffer or medium, or dissolve the dried sample directly in aqueous buffers by sonication. Solutions may be filter sterilized.
• Reconstitution: Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
• Other Notes: Longee, D.C., et al. 1991. Acta Neuropathologica82, 45.Livingston, P.O., et al. 1987. Proc Natl. Acad. Sci. USA84, 2911.Kundu, S.K., and Scott, D.D. 1982. J. Chromato.232, 19.Wakomari, S. 1981. Annu. Rev. Biochem.50, 733.
• Legal Information: CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany