Description

• General description: Sulfatides are majorly present in the brain and plasma membrane, especially in the outer leaflet. They are anionic sulfoglycolipids synthesized by oligodendrocytes and are the prime component of myelin sheath.[1] It constitutes 4 -7% weight of the myelin lipid.[2] Sulfatides are also associated with non-neural tissues including gall bladder, colon and kidney.[1] In the Golgi, 3′-phosphoadenosine5′phosphosulfate:cerebrosidesulfo transferase mediates the synthesis of sulfatides by 3-O-sulfation of the galactosylceramide. Lysosomes are the catabolism site for sulfatides, wherein arylsulfatase A mediates their breakdown.[1]
• Application: Sulfatides (Brain) has been used: as a lipid standard in electrospray ionization (ESI)-MS/MS analysis[3], as an anionic amphiphile for large unilamellar vesicles (LUVs) preparation[4] to test its myelin-associated axon growth inhibition functionality in retinal ganglion cells[2] as a calibrant in tandem mass spectrometry to quantify mouse brain myelin samples[5]
• Biochem/physiol Actions: Elevated sulfatides levels are implicated in renal, ovarian and adenocarcinoma. Accumulation of sulfatides in events of arylsulfatase A enzyme deficiency leads to metachromatic leukodystrophy, a lysosomal storage disease.[1] Sulfatide is a myelin-associated inhibitor of axon growth and is implicated in the axon regenerative failure.[2] It is a multifunctional sulfolipid, which plays a key role in immune response and insulin secretion. It binds to fibrinogen and elicits anticoagulant activity. Sulfatides are elevated in Parkinson′s disease and is a target for nervous disorder treatment. Sulfatideis also an inhibitor of oligodendrocyte differentiation. Sulfatides are utilized by bacteria for their adherence into host cells.[6] They are responsible for the inflammatory responses in chronic central nervous system illness.[7]
• Packaging: 5 mL Amber Glass Screw Cap Vial (131305P-10mg)