584222
Tetrahydrouridine
Potent competitive inhibitor of cytidine deaminase. Also available as a 100 mM solution in H2O.
Manufacturer: Millipore
CAS Number: 18771-50-1
Synonym(S): Tetrahydrouridine
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 10 MG | 584222-10-MG | In Stock | ₹ 16,250.01 |
584222 - 10 MG
In Stock
Quantity
1
Base Price: ₹ 16,250.01
GST (18%): ₹ 2,925.002
Total Price: ₹ 19,175.012
Quality Level
100
Assay
≥90% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freezedesiccated (hygroscopic)protect from light
color
white to off-white
solubility
water: 200 mg/mL
shipped in
wet ice
storage temp.
−20°C
InChI
1S/C9H16N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h4-8,12-15H,1-3H2,(H,10,16)/t4-,5?,6-,7-,8-/m1/s1
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | MilliporeSigma™ Calbiochem™ Tetrahydrouridine | MilliporeSigma™ | ₹ 23,283.44 | |
 | MilliporeSigma™ Calbiochem™ InSolution™ Tetrahydrouridine | MilliporeSigma™ | ₹ 29,561.84 | |
 | 18771-50-1 | Tetrahydrouridine | A2B Chem | ₹ 12,748.44 - ₹ 44,576.76 |
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Description
- General description: A potent competitive inhibitor of cytidine deaminase. Used in combination with cytosine arabinoside (Ara-C) to assess the anti-leukemic activity and anti-tumor activity of Ara-C in in vitro studies.
- Application: Oncotherapy resistance explained by Darwinian and Lamarckian models.: This research explores the mechanisms of oncotherapy resistance, combining Darwinian and Lamarckian models to provide a comprehensive understanding. The study highlights the role of Tetrahydrouridine in modulating therapy resistance pathways in cancer treatment (Saunthararajah et al., 2024).Neuroendocrine lineage commitment of small cell lung cancers can be leveraged into p53-independent non-cytotoxic therapy.: This study investigates the potential of using Tetrahydrouridine in non-cytotoxic therapies for small cell lung cancers, focusing on neuroendocrine lineage commitment and its implications for treatment efficacy (Biswas et al., 2023).In Vitro Interaction of Tetrahydrouridine with Key Human Nucleoside Transporters.: This study explores how Tetrahydrouridine interacts with human nucleoside transporters, shedding light on its mechanisms of action and potential as a therapeutic agent in biochemistry and pharmacology (Säll et al., 2023).Mycoplasma infection of cancer cells enhances anti-tumor effect of oxidized methylcytidines.: This research investigates how mycoplasma infection enhances the anti-tumor effects of oxidized methylcytidines, with Tetrahydrouridine playing a crucial role in the observed therapeutic outcomes (Pang et al., 2023).
- Packaging: Packaged under inert gas
- Warning: Toxicity: Standard Handling (A)
- Reconstitution: Following reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Aqueous stock solutions (at neutral or basic pH) are stable for up to 3 months at -20°C.
- Other Notes: Yusa, K., et al. 1995. Biochem. Biophys. Res. Commun. 206, 486.Bouffard, D.Y., et al. 1993. Biochem Pharmacol.45, 1857.Laliberte, J., et al. 1992. Cancer Chemotherap. Pharmacol.30, 7.Riva, C., et al. 1992. Chemotherapy38, 358. Yusa, K., et al. 1992. J. Biol. Chem. 267, 16848.Hanze, A.R. 1967. J. Am. Chem. Soc.89, 6720.
- Legal Information: CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Show Difference
Quality Level: 100
Assay: ≥90% (TLC)
form: solid
manufacturer/tradename: Calbiochem®
storage condition: OK to freezedesiccated (hygroscopic)protect from light
color: white to off-white
solubility: water: 200 mg/mL
shipped in: wet ice
storage temp.: −20°C
InChI: 1S/C9H16N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h4-8,12-15H,1-3H2,(H,10,16)/t4-,5?,6-,7-,8-/m1/s1
Quality Level:
100
Assay:
≥90% (TLC)
form:
solid
manufacturer/tradename:
Calbiochem®
storage condition:
OK to freezedesiccated (hygroscopic)protect from light
color:
white to off-white
solubility:
water: 200 mg/mL
shipped in:
wet ice
storage temp.:
−20°C
InChI:
1S/C9H16N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h4-8,12-15H,1-3H2,(H,10,16)/t4-,5?,6-,7-,8-/m1/s1
Quality Level: 100
Assay: ≥98.0% (HPLC)
form: __
manufacturer/tradename: __
storage condition: __
color: __
solubility: __
shipped in: __
storage temp.: 2-8°C
InChI: 1S/C23H25NO4/c25-22(26)16-11-9-15(10-12-16)13-24-23(27)28-14-21-19-7-3-1-5-17(19)18-6-2-4-8-20(18)21/h1-8,15-16,21H,9-14H2,(H,24,27)(H,25,26)/t15-,16-
Quality Level:
100
Assay:
≥98.0% (HPLC)
form:
__
manufacturer/tradename:
__
storage condition:
__
color:
__
solubility:
__
shipped in:
__
storage temp.:
2-8°C
InChI:
1S/C23H25NO4/c25-22(26)16-11-9-15(10-12-16)13-24-23(27)28-14-21-19-7-3-1-5-17(19)18-6-2-4-8-20(18)21/h1-8,15-16,21H,9-14H2,(H,24,27)(H,25,26)/t15-,16-
Quality Level: 100
Assay: ≥99.5% (GC)
form: liquid
manufacturer/tradename: __
storage condition: __
color: __
solubility: __
shipped in: __
storage temp.: __
InChI: __
Quality Level:
100
Assay:
≥99.5% (GC)
form:
liquid
manufacturer/tradename:
__
storage condition:
__
color:
__
solubility:
__
shipped in:
__
storage temp.:
__
InChI:
__
Quality Level: 100
Assay: ≥99.5% (GC)
form: liquid
manufacturer/tradename: __
storage condition: __
color: __
solubility: __
shipped in: __
storage temp.: __
InChI: __
Quality Level:
100
Assay:
≥99.5% (GC)
form:
liquid
manufacturer/tradename:
__
storage condition:
__
color:
__
solubility:
__
shipped in:
__
storage temp.:
__
InChI:
__