Description

• General description: 5α,6α-epoxycholestanol (5α,6α-EC) is generated by cholesterol epoxidation.[1] 5α,6α-epoxycholestanol-d7 is a deuterated derivative of 5α,6α-EC. It is catabolized by the enzyme cholesterol-5,6-epoxide hydrolase (ChEH) enzyme to 3β,5α,6β-triol.[1]
• Application: 5α,6α-epoxycholestanol-d7 has been used as an internal standard in isotope dilution-mass spectrometry analysis of heart mitochondrial samples.[2] It may be used as an internal standard in liquid chromatography with tandem mass spectrometry (LC-MS-MS) analysis of plasma samples.[3]
• Biochem/physiol Actions: 5α,6α-epoxycholestanol (5α,6α-EC) is a liver X receptor (LXR) antagonist.[4] 5α,6α-EC is employed in anticancer treatments.[1] It impairs redox state and affects atherogenesis.[5] The levels of 5α,6α-EC are elevated in hypercholesterolemia. It mediates steroid receptor coactivator (SRC) recruitment.[4]
• Packaging: 5 mL Amber Glass Screw Cap Vial (700047P-1mg)