700127P
7-keto-25-hydroxycholesterol
Manufacturer: Sigma Aldrich
CAS Number: 64907-23-9
Synonym(S): cholest-5-ene-7-one-3β,25-diol
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 MG | 700127P-1-MG | In Stock | ₹ 34,715.78 |
700127P - 1 MG
In Stock
Quantity
1
Base Price: ₹ 34,715.78
GST (18%): ₹ 6,248.84
Total Price: ₹ 40,964.62
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (700127P-1mg)pkg of 1 × 5 mg (700127P-5mg)
manufacturer/tradename
Avanti Polar Lipids 700127P
shipped in
dry ice
storage temp.
−20°C
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | 64907-23-9 | (3β)-3,25-Dihydroxycholest-5-en-7-one | A2B Chem | ₹ 16,684.20 - ₹ 59,635.32 |
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Description
- General description: 7-keto-25-hydroxycholesterol synthesis from 7-ketocholesterol is catalyzed by the enzyme cholesterol 25-hydroxylase.[1] 7β,25-dihydroxycholesterol (7β25OHC) is produced from the stereospecific reduction of 7k25OHC by the action of enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). 11β-HSD type 2 enzyme catalyzes the reverse conversion of 7β25OHC to 7k25OHC.[2]
- Application: 7-keto-25-hydroxycholesterol has been used as a substrate for 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) expressed in human embryonic kidney (HEK)-293 cells to test the oxoreduction functionality of the enzyme. It has also been used to test its effect on Epstein-Barr virus-induced seven-transmembrane receptor (EB12) activation.[2]
- Biochem/physiol Actions: 7-keto-25-hydroxycholesterol (7k25OHC) might interact with the cysteine-rich domain (CRD) of the smoothened (Smo) in the hedgehog pathway.[1] However, 7-keto-25-OHC is incapable of activating Smo.[3]
- Packaging: 5 mL Amber Glass Screw Cap Vial (700127P-1mg)
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
No data available
Flash Point(C)
No data available
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form: powder
packaging: pkg of 1 × 1 mg (700127P-1mg)pkg of 1 × 5 mg (700127P-5mg)
manufacturer/tradename: Avanti Polar Lipids 700127P
shipped in: dry ice
storage temp.: −20°C
Assay:
>99% (TLC)
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powder
packaging:
pkg of 1 × 1 mg (700127P-1mg)pkg of 1 × 5 mg (700127P-5mg)
manufacturer/tradename:
Avanti Polar Lipids 700127P
shipped in:
dry ice
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−20°C
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