Description

• General description: 1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] nitrilotriacetic acid (NTA) (18:1 DGS-NTA(Ni)) is a conjugated phospholipid[1] that contains nickel.[2] NTA chelates with four of the six coordination sites present in nickel ion.[3]
• Application: 1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] (nickel salt) (18:1 DGS-NTA(Ni)) has been used: in the preparation of liposomes with porphyrin-phospholipid (PoP) conjugate for protein and peptide binding studies[1] in the preparation of nanosize multillamelar vesicles (NMVs) for antigen delivery studies[2]as a component of small unilamellar vesicle (SUV) for planar lipid membrane (PM) preparation[4]
• Biochem/physiol Actions: 1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] nitrilotriacetic acid (NTA) (18:1 DGS-NTA(Ni)) is useful in structural biology especially to bind recombinant histidine tagged proteins.[1] Though useful, being nanoparticulate it has stability problems in biological samples. So NTA-lipid conjugate is majorly used as liposomes or as a coating to nanoparticle.[1] DGS-NTA (Ni) based nanosize multillamelar vesicles (NMVs) are potent vaccine delivery system.[2]
• Packaging: 5 mL Clear Glass Sealed Ampule (790404P-10mg)