Description

• General description: 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt) (18:0 PE-DTPA (Gd)) are sparing soluble in alcohol and well soluble in a solvent mixture consisting of chloroform and methanol in the ratio of 4:1, v/v.[1] 18:0 PE-DTPA (Gd) is a synthetic phospholipid derivative ethanolamine.[2] The DTPA is attached to gadolinium ion.
• Application: 18:0 PE-DTPA (Gd) has been used: as a component of Gadolinium-liposome preparation[3] in the nanodics preparation for nuclear magnetic resonance (NMR) studies[4]in construction of cysteine-arginine-glutamic acid-lysine alanine (CREKA) based peptide amphiphile micelles (PAMs) for the magnetic resonance imaging (MRI) studies[5] as a spin-labeled lipid for supported lipid bilayer incorporation for cryo transmission electron microscopy studies[1]
• Biochem/physiol Actions: 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt) (18:0 PE-DTPA (Gd)) phospholipid based liposomes are useful in magnetic resonance imaging (MRI) and multimodal imaging. Apart from being a MRI contrast agent, PE-DTPA (Gd) liposome is also flexible for modification for binding different targets using copper–free click–chemistry methodology.[3]
• Packaging: 5 mL Amber Glass Screw Cap Vial (791275P-5mg)