Description

• General description: 18:1-2:0 DG, also called 1-oleoyl-2-acetyl-sn-glycerol (OADG), is a synthetic analog of diacyl glycerol (DAG) and is membrane permeable.[1]
• Application: 18:1-2:0 DG (1-oleoyl-2-acetyl-sn-glycerol) has been used as a diacyl glycerol (DAG) analog to test its impact on DAG-sensitive channels in thalamocortical (TC) neurons.[2] It may be used as an internal standard for retention time calibration in ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF MS) for blood sample lipid quantification.[3] It may also be used as a protein kinase C (PKC) activator in adrenal glands.[4]
• Biochem/physiol Actions: 1-oleoyl-2-acetyl-sn-glycerol (OAG) has ability to activate protein kinase C (PKC) .[4] It also inhibits TWIK-related acid-sensitive (TASK)-like potassium channels in peripheral arterial chemoreceptors.[2] OAG stimulates 5-lipooxygenase (5-LO) in human polymorphonuclear leukocytes (PMNL).[5] It also inhibits mitochondrial permeability transition pore (MPTP) formation and prevents fatty acid release and necrosis in lung fibroblasts.[6]
• Packaging: 30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (800100C-10mg)
• Storage and Stability: Diacylglycerols are conveniently stored in chloroform solutions in glass vials with PTFE-lined caps at -20°C. Under these conditions acyl migration is minimal. Avoid plastic when handling chloroform solutions.
• Other Notes: Delivery to cells: Dry samples of diacylglycerol in chloroform, using a stream of nitrogen. Dissolve the residue in an appropriate volume of ethanol or DMSO, then dilute to the desired aqueous medium.