Brain PI(4,5)P2
Manufacturer: Sigma Aldrich
CAS Number: 383907-42-4
Synonym(S): Brain PI(4,5)P2, L-α-phosphatidylinositol-4,5-bisphosphate (Brain, Porcine) (ammonium salt), chloroform:methanol:water (20:9:1)
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 MG | 840046X-1-MG | In Stock | ₹ 45,887.40 |
| 5 MG | 840046X-5-MG | In Stock | ₹ 1,88,725.05 |
| 10 MG | 840046X-10-MG | In Stock | ₹ 3,27,615.53 |
| 25 MG | 840046X-25-MG | In Stock | ₹ 7,26,948.00 |
840046X - 1 MG
In Stock
Quantity
1
Base Price: ₹ 45,887.40
GST (18%): ₹ 8,259.732
Total Price: ₹ 54,147.132
Assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 1 mL (840046X-10mg)pkg of 1 × 1 mL (840046X-1mg)pkg of 1 × 1 mL (840046X-5mg)pkg of 1 × 2.5 mL (840046X-25mg)
manufacturer/tradename
Avanti Polar Lipids
concentration
1 mg/mL (840046X-1mg)10 mg/mL (840046X-10mg)10 mg/mL (840046X-25mg)5 mg/mL (840046X-5mg)
lipid type
phosphoglycerides
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@@](COP(O[C@H]1[C@H](O)[C@@H](OP([O-])(O)=O)[C@H](OP(O)([O-])=O)[C@@H](O)[C@H]1O)([O-])=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+].[NH4+]
InChI
1S/C47H85O19P3.3H3N/c1-3-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-36-41(49)63-39(37-61-40(48)35-33-31-29-27-25-23-21-18-16-14-12-10-8-6-4-2)38-62-69(59,60)66-45-42(50)43(51)46(64-67(53,54)55)47(44(45)52)65-68(56,57)58;;;/h11,13,17,19,22,24,28,30,39,42-47,50-52H,3-10,12,14-16,18,20-21,23,25-27,29,31-38H2,1-2H3,(H,59,60)(H2,53,54,55)(H2,56,57,58);3*1H3/b13-11-,19-17-,24-22-,30-28-;;;/t39-,42?,43+,44?,45-,46?,47?;;;/m1.../s1
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Avanti Polar Lipids L-α-phosphatidylinositol-4,5-bisphosphate (Brain, Porcine) (ammonium salt), 383907-42-4, MFCD28901390, 10 mg | Avanti Polar Lipids | ₹ 3,59,541.94 | |
 | Brain PI(4,5)P2 | Sigma Aldrich | ₹ 48,604.25 - ₹ 7,68,813.15 | |
 | 383907-42-4 | L-α-phosphatidylinositol-4,5-bisphosphate (Brain, Porcine) (ammonium salt) | A2B Chem | ₹ 1,62,820.68 - ₹ 19,71,815.76 |
Related Products
Description
- General description: Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT.
- Application: Brain PI(4,5)P2 has been used in the preparation of liposomes for dynamin-catalyzed fission assay[2] and as a constituent in the lipid mixture for dual polarisation interferometry(DPI)[3]
- Biochem/physiol Actions: Phosphatidyl inositol (4,5) bisphosphate (PI(4,5)P2) plays a key role in the early stages of vesicle formation. It functions in the recruitment of endocytic coats by binding to variety of proteins involved in endocytic trafficking.[4] PI(4,5)P2 is hydrolysed by phospholipase C to yield the signaling molecules diacylglycerol (DAG) and phosphatidyl inositol (3,4,5) triphosphate (PI(3,4,5)P3). PI(4,5)P2 is required for the functioning of many ion channels.[1]
- Packaging: 5 mL Clear Glass Sealed Ampule (840046X-10mg)
SAFETY INFORMATION
Pictograms
Signal Word
Danger
Hazard Statements
Precautionary Statements
P210 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311 - P305 + P351 + P338
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 1 - STOT SE 3
Target Organs
Central nervous system, Eyes,Central nervous system, Liver,Kidney
WGK
WGK 3
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Show Difference
Assay: >99% (TLC)
form: liquid
packaging: pkg of 1 × 1 mL (840046X-10mg)pkg of 1 × 1 mL (840046X-1mg)pkg of 1 × 1 mL (840046X-5mg)pkg of 1 × 2.5 mL (840046X-25mg)
manufacturer/tradename: Avanti Polar Lipids
concentration: 1 mg/mL (840046X-1mg)10 mg/mL (840046X-10mg)10 mg/mL (840046X-25mg)5 mg/mL (840046X-5mg)
lipid type: phosphoglycerides
shipped in: dry ice
storage temp.: −20°C
SMILES string: [H][C@@](COP(O[C@H]1[C@H](O)[C@@H](OP([O-])(O)=O)[C@H](OP(O)([O-])=O)[C@@H](O)[C@H]1O)([O-])=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+].[NH4+]
InChI: 1S/C47H85O19P3.3H3N/c1-3-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-36-41(49)63-39(37-61-40(48)35-33-31-29-27-25-23-21-18-16-14-12-10-8-6-4-2)38-62-69(59,60)66-45-42(50)43(51)46(64-67(53,54)55)47(44(45)52)65-68(56,57)58;;;/h11,13,17,19,22,24,28,30,39,42-47,50-52H,3-10,12,14-16,18,20-21,23,25-27,29,31-38H2,1-2H3,(H,59,60)(H2,53,54,55)(H2,56,57,58);3*1H3/b13-11-,19-17-,24-22-,30-28-;;;/t39-,42?,43+,44?,45-,46?,47?;;;/m1.../s1
Assay: >99% (TLC)
form: liquid
packaging: pkg of 1 × 2.5 mL (840051C-25mg)pkg of 2 × 20 mL (840051C-1g)pkg of 2 × 4 mL (840051C-200mg)pkg of 5 × 4 mL (840051C-500mg)
manufacturer/tradename: Avanti Polar Lipids
concentration: 10 mg/mL (840051C-25mg)25 mg/mL (840051C-1g)25 mg/mL (840051C-200mg)25 mg/mL (840051C-500mg)
lipid type: phospholipidsphosphoglycerides
shipped in: dry ice
storage temp.: −20°C
SMILES string: __
InChI: 1S/C42H82NO8P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h20-21,40H,6-19,22-39H2,1-5H3/b21-20-/t40-/m1/s1
Assay: >99% (TLC)
form: powder
packaging: pkg of 1 × 1 g (840051P-1g)pkg of 2 × 100 mg (840051P-200mg)pkg of 5 × 100 mg (840051P-500mg)pkg of 1 × 25 mg (840051P-25mg)
manufacturer/tradename: Avanti Polar Lipids
concentration: __
lipid type: phosphoglyceridesphospholipids
shipped in: dry ice
storage temp.: −20°C
SMILES string: [O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)=O
InChI: 1S/C42H82NO8P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h20-21,40H,6-19,22-39H2,1-5H3/b21-20-/t40-/m1/s1
