860477P
1-desoxymethylsphingosine
Manufacturer: Sigma Aldrich
CAS Number: 1246303-16-1
Synonym(S): 1-Deoxymethylsphingosine
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 MG | 860477P-1-MG | In Stock | ₹ 34,715.78 |
860477P - 1 MG
In Stock
Quantity
1
Base Price: ₹ 34,715.78
GST (18%): ₹ 6,248.84
Total Price: ₹ 40,964.62
form
powder
packaging
pkg of 1 × 1 mg (860477P-1mg)
manufacturer/tradename
Avanti Polar Lipids 860477P
lipid type
sphingolipidsbioactive lipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
CCCCCCCCCCCCC/C=C/[C@](O)([H])CN
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
1246303-16-1 | 1-desoxyMethylsphingosine (M17 | -- | ₹ 1,15,611.00 |
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Description
- General description: 1-desoxymethylsphingosine is synthesized from glycine in the presence of the enzyme serine palmitoyltransferase (SPT).[1]
- Application: 1-desoxymethylsphingosine may be used for the complex preparation with bovine serum albumin for cytotoxicity testing in MN9D dopaminergic neuroblastoma cell line.[2]
- Biochem/physiol Actions: 1-desoxymethylsphingosine is less neurotoxic compared to 1-desoxysphingosine in dorsal root ganglion neuronscultures[3] Mutations in the palmitoyltransferase (SPT) in hereditary sensory neuropathy type 1 (HSAN-1), due to altered substrate specificity 1-desoxymethylsphinganine and 1-deoxy-sphinganine which are further converted to -deoxy(methyl)-ceramide and 1-deoxy(methyl)-sphingosine (1-deoxy(methyl)-SO). However, they lack the hydroxyl group essential for glycosphingolipid generation, resulting in accumulation of intermediate products.[4]
- Packaging: 5 mL Amber Glass Screw Cap Vial (860477P-1mg)
SAFETY INFORMATION
WGK
WGK 3