A4487
Aphidicolin, Ready Made Solution
from Nigrospora sphaerica
Manufacturer: Sigma Aldrich
CAS Number: 38966-21-1
Synonym(S): ICI 69653, NSC-234714
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 ML | A4487-1-ML | In Stock | ₹ 15,057.58 |
A4487 - 1 ML
In Stock
Quantity
1
Base Price: ₹ 15,057.58
GST (18%): ₹ 2,710.364
Total Price: ₹ 17,767.944
biological source
Nigrospora sphaerica
Quality Level
200
vapor pressure
0.55 hPa ( 20 °C)
form
liquid
color
clear colorless
solubility
H2O: miscible (completely)
antibiotic activity spectrum
neoplasticsviruses
Mode of action
DNA synthesis | interferesenzyme | inhibits
storage temp.
−20°C
InChI
1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ Aphidicolin | Tocris Bioscience™ | ₹ 13,629.71 | |
 | Enzo Life Sciences (+)-Aphidicolin (1mg). CAS: 38966-21-1 | Enzo Life Sciences | ₹ 10,626.55 | |
 | AdipoGen (+)-Aphidicolin,Chemical. CAS: 38966-21-1 | AdipoGen | ₹ 6,395.61 | |
| | Aphidicolin, ≥95% (HPLC), MilliporeSigma™ Supelco™ | MilliporeSigma Supelco | ₹ 1,15,249.32 | |
 | Sigma Aldrich Fine Chemicals Biosciences Aphidicolin from Nigrospora sphaerica | 38966-21-1 | MFCD00083214 | 1mg | Sigma Aldrich Fine Chemicals Biosciences | ₹ 14,254.30 | |
 | Aphidicolin | Supelco | ₹ 97,565.73 | |
| | Aphidicolin, Ready Made Solution | Sigma Aldrich | ₹ 15,057.58 | |
 | 38966-21-1 | 8,11|á-Methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol,tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, (3R,4R,4aR,6aS,8R,9R,11aS,11bS)- | A2B Chem | ₹ 23,443.44 |
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Description
- General description: Aphidicolin is a tetracyclic diterpene with antiviral and antimitotic properties used for cell cycle synchronization in various cell lines.[1]
- Application: Aphidicolin, from Nigrospora sphaerica, was used for cell cycle synchronization of tobacco BY-2 cells. It is used to block the entry of cells into S-phase.[2]
- Biochem/physiol Actions: Aphidicolin specifically inhibits DNA polymerase α that is responsible for DNA replication. It also inhibits α-like DNA polymerases of plants and yeasts but does not inhibit synthesis of RNA and proteins. Aphidicolin competes for the dCTP-specific binding site on DNA polymerase α specifically. Aphidicolin has antiviral and antimitotic properties. It blocks the cell cycle at S phase. It has been shown to induce apoptosis in HeLa cells.[3]
- Packaging: 1 ml
- Physical form: Aphidicolin Ready Made Solution supplied as a 1 mg/ml solution in DMSO.
- Other Notes: Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids
SAFETY INFORMATION
WGK
WGK 1
Flash Point(F)
closed cup
Flash Point(C)
closed cup
Compare Similar Items
Show Difference
biological source: Nigrospora sphaerica
Quality Level: 200
vapor pressure: 0.55 hPa ( 20 °C)
form: liquid
color: clear colorless
solubility: H2O: miscible (completely)
antibiotic activity spectrum: neoplasticsviruses
Mode of action: DNA synthesis | interferesenzyme | inhibits
storage temp.: −20°C
InChI: 1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
biological source:
Nigrospora sphaerica
Quality Level:
200
vapor pressure:
0.55 hPa ( 20 °C)
form:
liquid
color:
clear colorless
solubility:
H2O: miscible (completely)
antibiotic activity spectrum:
neoplasticsviruses
Mode of action:
DNA synthesis | interferesenzyme | inhibits
storage temp.:
−20°C
InChI:
1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
biological source: __
Quality Level: __
vapor pressure: __
form: __
color: __
solubility: __
antibiotic activity spectrum: __
Mode of action: __
storage temp.: __
InChI: __
biological source:
__
Quality Level:
__
vapor pressure:
__
form:
__
color:
__
solubility:
__
antibiotic activity spectrum:
__
Mode of action:
__
storage temp.:
__
InChI:
__
biological source: __
Quality Level: 200
vapor pressure: __
form: powder
color: __
solubility: __
antibiotic activity spectrum: __
Mode of action: __
storage temp.: __
InChI: 1S/5BO3.9H3N.4H2O/c5*2-1(3)4;;;;;;;;;;;;;/h;;;;;9*1H3;4*1H2/q5*-3;;;;;;;;;;;;;/p+9
biological source:
__
Quality Level:
200
vapor pressure:
__
form:
powder
color:
__
solubility:
__
antibiotic activity spectrum:
__
Mode of action:
__
storage temp.:
__
InChI:
1S/5BO3.9H3N.4H2O/c5*2-1(3)4;;;;;;;;;;;;;/h;;;;;9*1H3;4*1H2/q5*-3;;;;;;;;;;;;;/p+9
biological source: goat
Quality Level: 200
vapor pressure: __
form: saline suspension
color: __
solubility: __
antibiotic activity spectrum: __
Mode of action: __
storage temp.: __
InChI: __
biological source:
goat
Quality Level:
200
vapor pressure:
__
form:
saline suspension
color:
__
solubility:
__
antibiotic activity spectrum:
__
Mode of action:
__
storage temp.:
__
InChI:
__