D5011
5′-Deoxy-5′-(methylthio)adenosine
Manufacturer: Sigma Aldrich
CAS Number: 2457-80-9
Synonym(S): Methylthioadenosine, MTA
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 25 MG | D5011-25-MG | In Stock | ₹ 7,361.00 |
| 100 MG | D5011-100-MG | In Stock | ₹ 21,801.55 |
| 250 MG | D5011-250-MG | In Stock | ₹ 35,094.65 |
| 1 G | D5011-1-G | In Stock | ₹ 1,12,580.00 |
D5011 - 25 MG
In Stock
Quantity
1
Base Price: ₹ 7,361.00
GST (18%): ₹ 1,324.98
Total Price: ₹ 8,685.98
biological source
synthetic (organic)
Quality Level
200
Assay
≥98% (HPLC)
form
powder
solubility
DMF: 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
storage temp.
−20°C
SMILES string
CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
InChI
1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1
InChI key
WUUGFSXJNOTRMR-IOSLPCCCSA-N
Gene Information
human ... ADORA2B(136) , ADORA3(140) mouse ... Mtap(66902) rat ... Adora1(29290) , Adora2a(25369)
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Sigma Aldrich Fine Chemicals Biosciences 5′-Deoxy-5′-(methylthio)adenosine | 2457-80-9 | MFCD00010533 | 25mg | Sigma Aldrich Fine Chemicals Biosciences | ₹ 8,076.86 | |
 | Cayman Chemical 5'-Deoxy-5'-methylthioadenosine, 2457-80-9, 25 mg | Cayman Chemical | ₹ 4,346.45 | |
 | Sigma Aldrich Fine Chemicals Biosciences 5′-Deoxy-5′-(methylthio)adenosine | 2457-80-9 | MFCD00010533 | 100 mg | Sigma Aldrich Fine Chemicals Biosciences | ₹ 24,002.15 | |
 | eMolecules 5'-S-Methyl-5'-thioadenosine | 2457-80-9 | | 1g | eMolecules | ₹ 22,040.26 | |
 | 5'-Methylthioadenosine | ChemScene | ₹ 3,080.16 - ₹ 69,389.16 | |
 | 2457-80-9 | 5'-S-Methyl-5'-thioadenosine | A2B Chem | ₹ 3,080.16 - ₹ 66,480.12 |
Description
- Application: 5′-Deoxy-5′-(methylthio)adenosine has been used as a protein methylation inhibitor to reduce E2F transcription factor 1 (E2F1) protein abundance in hepatocellular carcinoma (HCC) cells.[1] It has also been used to inhibit histone methylation modification and study its role in hypoxia inducible factor-1 (Hif-1) nuclear transport.[2]
- Biochem/physiol Actions: 5′-Deoxy-5′-(methylthio)adenosine (Methylthioadenosine) may be used as a substrate to study the specificity and kinetics of 5′-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28), a tumor suppressor gene expressed enzyme that supports the S-adenosylmethionine (AdoMet) and methionine salvage pathways.
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Compare Similar Items
Show Difference
biological source: synthetic (organic)
Quality Level: 200
Assay: ≥98% (HPLC)
form: powder
solubility: DMF: 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
storage temp.: −20°C
SMILES string: CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
InChI: 1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1
InChI key: WUUGFSXJNOTRMR-IOSLPCCCSA-N
Gene Information: human ... ADORA2B(136) , ADORA3(140) mouse ... Mtap(66902) rat ... Adora1(29290) , Adora2a(25369)
biological source:
synthetic (organic)
Quality Level:
200
Assay:
≥98% (HPLC)
form:
powder
solubility:
DMF: 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
storage temp.:
−20°C
SMILES string:
CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
InChI:
1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1
InChI key:
WUUGFSXJNOTRMR-IOSLPCCCSA-N
Gene Information:
human ... ADORA2B(136) , ADORA3(140) mouse ... Mtap(66902) rat ... Adora1(29290) , Adora2a(25369)
biological source: bovine pancreas
Quality Level: 300
Assay: __
form: lyophilized powder
solubility: 0.15 M NaCl: soluble 5.0 mg/mL, clear, colorless
storage temp.: __
SMILES string: __
InChI: __
InChI key: __
Gene Information: __
biological source:
bovine pancreas
Quality Level:
300
Assay:
__
form:
lyophilized powder
solubility:
0.15 M NaCl: soluble 5.0 mg/mL, clear, colorless
storage temp.:
__
SMILES string:
__
InChI:
__
InChI key:
__
Gene Information:
__
biological source: __
Quality Level: 500
Assay: __
form: powder
solubility: __
storage temp.: 2-8°C
SMILES string: __
InChI: __
InChI key: __
Gene Information: __
biological source:
__
Quality Level:
500
Assay:
__
form:
powder
solubility:
__
storage temp.:
2-8°C
SMILES string:
__
InChI:
__
InChI key:
__
Gene Information:
__
biological source: __
Quality Level: 200
Assay: ≥99%
form: liquid
solubility: __
storage temp.: −20°C
SMILES string: [Na+].[Na+].[Na+].NC1=Nc2c(ncn2[C@H]3C[C@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)O3)C(=O)N1
InChI: 1S/C10H16N5O13P3.3Na/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17);;;/q;3*+1/p-3/t4-,5+,6+;;;/m0.../s1
InChI key: __
Gene Information: __
biological source:
__
Quality Level:
200
Assay:
≥99%
form:
liquid
solubility:
__
storage temp.:
−20°C
SMILES string:
[Na+].[Na+].[Na+].NC1=Nc2c(ncn2[C@H]3C[C@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)O3)C(=O)N1
InChI:
1S/C10H16N5O13P3.3Na/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17);;;/q;3*+1/p-3/t4-,5+,6+;;;/m0.../s1
InChI key:
__
Gene Information:
__