D5011

5′-Deoxy-5′-(methylthio)adenosine

Manufacturer: Sigma Aldrich

CAS Number: 2457-80-9

Synonym(S): Methylthioadenosine, MTA

Select a Size

Pack Size SKU Availability Price
25 MG D5011-25-MG In Stock ₹ 7,361.00
100 MG D5011-100-MG In Stock ₹ 21,801.55
250 MG D5011-250-MG In Stock ₹ 35,094.65
1 G D5011-1-G In Stock ₹ 1,12,580.00

D5011 - 25 MG

₹ 7,361.00

In Stock

Quantity

1

Base Price: ₹ 7,361.00

GST (18%): ₹ 1,324.98

Total Price: ₹ 8,685.98

biological source

synthetic (organic)

Quality Level

200

Assay

≥98% (HPLC)

form

powder

solubility

DMF: 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow

storage temp.

−20°C

SMILES string

CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23

InChI

1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1

InChI key

WUUGFSXJNOTRMR-IOSLPCCCSA-N

Gene Information

human ... ADORA2B(136) , ADORA3(140) mouse ... Mtap(66902) rat ... Adora1(29290) , Adora2a(25369)

Other Options

Image Product Name Manufacturer Price Range
50-183-2645
Sigma Aldrich Fine Chemicals Biosciences 5′-Deoxy-5′-(methylthio)adenosine | 2457-80-9 | MFCD00010533 | 25mg
Sigma Aldrich Fine Chemicals Biosciences ₹ 8,076.86
NC1565026
Cayman Chemical 5'-Deoxy-5'-methylthioadenosine, 2457-80-9, 25 mg
Cayman Chemical ₹ 4,346.45
50-183-2642
Sigma Aldrich Fine Chemicals Biosciences 5′-Deoxy-5′-(methylthio)adenosine | 2457-80-9 | MFCD00010533 | 100 mg
Sigma Aldrich Fine Chemicals Biosciences ₹ 24,002.15
50-218-4025
eMolecules​ 5'-S-Methyl-5'-thioadenosine | 2457-80-9 | | 1g
eMolecules​ ₹ 22,040.26
CS-0012983
5'-Methylthioadenosine
ChemScene ₹ 3,080.16 - ₹ 69,389.16
AB24997
2457-80-9 | 5'-S-Methyl-5'-thioadenosine
A2B Chem ₹ 3,080.16 - ₹ 66,480.12

Description

  • Application: 5′-Deoxy-5′-(methylthio)adenosine has been used as a protein methylation inhibitor to reduce E2F transcription factor 1 (E2F1) protein abundance in hepatocellular carcinoma (HCC) cells.[1] It has also been used to inhibit histone methylation modification and study its role in hypoxia inducible factor-1 (Hif-1) nuclear transport.[2]
  • Biochem/physiol Actions: 5′-Deoxy-5′-(methylthio)adenosine (Methylthioadenosine) may be used as a substrate to study the specificity and kinetics of 5′-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28), a tumor suppressor gene expressed enzyme that supports the S-adenosylmethionine (AdoMet) and methionine salvage pathways.

SAFETY INFORMATION

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Compare Similar Items

Show Difference

Img

Sigma Aldrich

D5011

--


biological source:
synthetic (organic)

Quality Level:
200

Assay:
≥98% (HPLC)

form:
powder

solubility:
DMF: 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow

storage temp.:
−20°C

SMILES string:
CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23

InChI:
1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1

InChI key:
WUUGFSXJNOTRMR-IOSLPCCCSA-N

Gene Information:
human ... ADORA2B(136) , ADORA3(140) mouse ... Mtap(66902) rat ... Adora1(29290) , Adora2a(25369)

Img

Sigma Aldrich

D5025

Type IV, lyophilized powder, ≥2,000...


biological source:
bovine pancreas

Quality Level:
300

Assay:
__

form:
lyophilized powder

solubility:
0.15 M NaCl: soluble 5.0 mg/mL, clear, colorless

storage temp.:
__

SMILES string:
__

InChI:
__

InChI key:
__

Gene Information:
__

Img

Sigma Aldrich

D5030

Without glucose, L-glutamine, pheno...


biological source:
__

Quality Level:
500

Assay:
__

form:
powder

solubility:
__

storage temp.:
2-8°C

SMILES string:
__

InChI:
__

InChI key:
__

Gene Information:
__

Img

Sigma Aldrich

D5038

100 mM (pH 7)...


biological source:
__

Quality Level:
200

Assay:
≥99%

form:
liquid

solubility:
__

storage temp.:
−20°C

SMILES string:
[Na+].[Na+].[Na+].NC1=Nc2c(ncn2[C@H]3C[C@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)O3)C(=O)N1

InChI:
1S/C10H16N5O13P3.3Na/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17);;;/q;3*+1/p-3/t4-,5+,6+;;;/m0.../s1

InChI key:
__

Gene Information:
__