Ionomycin calcium salt

Description

• General description: Ionomycin is a calcium ionophore commonly derived from produced by the bacterium Streptomyces conglobatus, which means that it helps to transport calcium ions across cell membranes. It is a powerful tool for studying calcium signaling and its role in various biological processes, including cell activation, secretion, proliferation, and apoptosis.Ionomycin is commonly used in cell biology experiments to induce a rapid and controlled increase in intracellular calcium levels. This allows to study the downstream effects of calcium signaling pathways, such as the activation of enzymes, the release of hormones, and the changes in gene expression.Ionomycin is also used to investigate the role of calcium in specific cellular processes, such as cell death, immune cell activation, and muscle contraction. For example, ionomycin can be used to induce apoptosis in cancer cells, study the activation of T cells, and investigate the role of calcium in muscle contraction.
• Application: Ionomycin finds application in:Study of calcium signaling and its role in various biological processesInvestigation of intracellular calcium levels, calcium-dependent enzymes, and cellular responses triggered by calcium influxInduction of a rapid and controlled increase in intracellular calcium levels in cell biology experimentsElucidation of specific cellular mechanisms and signaling pathways in combination with other substances, such as fluorescent calcium indicators or protein kinase activatorsIonomycin has been used: to induce central demyelination[1]inhibit adrenal bovine TREK-1 channels[2]to regulate cell division of mature human B cells[3]
• Biochem/physiol Actions: Ionomycin is an ionophoric antibiotic that binds Pb2+ and Ca2+, and serves as an effective mobile carrier of both cations.Mode of Action: Facilitates the transfer of calcium ions (Ca2+) across biological membranes Antimicrobial Spectrum: Active against Gram-Positive bacteria
• Features and Benefits: Ready available solution reduce the need for preparation timeEfficient choice for studying calcium signaling and its role in various biological processesAllows for rapid and controlled manipulation of intracellular calcium levelsVersatile and widely used in cell biology research
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