R8781
Rapamycin
from Streptomyces hygroscopicus, ≥95% (HPLC), solution, mTOR inhibitor
Manufacturer: Sigma Aldrich
Synonym(S): 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine solution
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 200 μL | R8781-200-μL | In Stock | ₹ 29,000.18 |
R8781 - 200 μL
In Stock
Quantity
1
Base Price: ₹ 29,000.18
GST (18%): ₹ 5,220.032
Total Price: ₹ 34,220.212
biological source
Streptomyces hygroscopicus
Quality Level
300
vapor pressure
0.56 hPa ( 20 °C)
Assay
≥95% (HPLC)
form
solution
autoignition temp.
301 °C
concentration
2.5 mg/mL in DMSO (2.74 mM)
color
colorless to yellow
antibiotic activity spectrum
fungiyeast
Mode of action
enzyme | inhibits
Related Products
Description
- General description: Rapamycin is a macrocyclic triene antibiotic possessing potent immunosuppressant and anticancer activity. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. The effectors of mTOR action include 4EBP1 and S6K1.
- Application: Rapamycin has been used:as a supplement in mTeSR1 medium to culture induced pluripotent stem cell (iPSC) colonies for induction of autophagy signaling[2]to treat the Drosophila S2 cells at 65-70% confluence,to measure protein synthesis[3]to stimulate autophagy in ovarian cancer cells[4]
- Packaging: 200uL
- Other Notes: 2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research
SAFETY INFORMATION
WGK
WGK 1
Flash Point(F)
188.6 °F
Flash Point(C)
87 °C
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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biological source: Streptomyces hygroscopicus
Quality Level: 300
vapor pressure: 0.56 hPa ( 20 °C)
Assay: ≥95% (HPLC)
form: solution
autoignition temp.: 301 °C
concentration: 2.5 mg/mL in DMSO (2.74 mM)
color: colorless to yellow
antibiotic activity spectrum: fungiyeast
Mode of action: enzyme | inhibits
biological source:
Streptomyces hygroscopicus
Quality Level:
300
vapor pressure:
0.56 hPa ( 20 °C)
Assay:
≥95% (HPLC)
form:
solution
autoignition temp.:
301 °C
concentration:
2.5 mg/mL in DMSO (2.74 mM)
color:
colorless to yellow
antibiotic activity spectrum:
fungiyeast
Mode of action:
enzyme | inhibits
biological source: __
Quality Level: __
vapor pressure: __
Assay: __
form: __
autoignition temp.: __
concentration: __
color: __
antibiotic activity spectrum: __
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Assay:
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antibiotic activity spectrum:
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biological source: rat midbrain
Quality Level: 100
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rat midbrain
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100
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biological source: rat forebrain striatum
Quality Level: 100
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biological source:
rat forebrain striatum
Quality Level:
100
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