Leptomycin B
from Streptomyces sp., ≥95% (HPLC), solution, anti-fungal antibiotic
Manufacturer: Sigma Aldrich
CAS Number: 87081-35-4
Synonym(S): Antibiotic CI 940, Elactocin, LMB, Mantuamycin
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 0.5 μG | L2913-0.5-μG | In Stock | ₹ 7,415.13 |
| 5 μG | L2913-5-μG | In Stock | ₹ 46,569.15 |
L2913 - 0.5 μG
In Stock
Quantity
1
Base Price: ₹ 7,415.13
GST (18%): ₹ 1,334.723
Total Price: ₹ 8,749.853
product name
Leptomycin B solution from Streptomyces sp., ≥95% (HPLC), Supplied in methanol: water (7:3)
Quality Level
300
Assay
≥95% (HPLC)
storage condition
protect from light
antibiotic activity spectrum
fungi
Mode of action
protein synthesis | interferes
shipped in
dry ice
storage temp.
−20°C
SMILES string
CCC(\C=C\[C@@H]1OC(=O)C=C[C@@H]1C)=C\[C@H](C)C\C=C\C(C)=C\[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C\C(C)=C\C(O)=O
InChI
1S/C33H48O6/c1-9-28(14-15-29-24(5)13-16-31(36)39-29)19-22(3)12-10-11-21(2)17-25(6)32(37)27(8)33(38)26(7)18-23(4)20-30(34)35/h10-11,13-17,19-20,22,24-27,29,33,38H,9,12,18H2,1-8H3,(H,34,35)/b11-10+,15-14+,21-17+,23-20+,28-19-/t22-,24+,25-,26+,27-,29+,33-/m1/s1
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Cayman Chemical Leptomycin B, 87081-35-4, 25 g | Cayman Chemical | ₹ 12,320.64 | |
 | 87081-35-4 | Leptomycin B from Streptomyces sp | A2B Chem | ₹ 21,218.88 - ₹ 72,383.76 |
Related Products
Description
- General description: Leptomycin B is an anti-fungal antibiotic, anti-tumor cytotoxin that inhibits CRM1-dependent, NES-dependent nucleo-cytoplasmic translocation (nuclear export inhibitor). NES containing proteins include HIV-1 REV; actin, c-Abl, cyclin B1, MDM2/p53, I?B, MPF, PKA and MEK.
- Biochem/physiol Actions: Leptomycin B is an unsaturated, branched-chain fatty acid, and is an important tool in the study of nuclear export. Leptomycin B is a specific inhibitor of proteins containing nuclear export signal. Leptomycin B inhibits nucleo-cytoplasmic translocation of molecules such as the HIV-1 Rev protein and Rev-dependent export of mRNA. The addition of very small amounts to fibroblasts causes accumulation of MEK in the nucleus. Other proteins that are influenced by leptomycin B are actin, c-Abl, cyclin B1, MDM2/p53, IκB, MPF, and PKA. The suggested inhibition mechanism involves the direct binding of leptomycin B to CRM1, which blocks the binding of CRM1 to proteins containing the nuclear export signal, via the interaction with cysteine residue in CRM1 control conserved region.
SAFETY INFORMATION
Pictograms
Signal Word
Danger
Hazard Statements
Precautionary Statements
P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
Target Organs
Eyes
WGK
WGK 2
Flash Point(F)
closed cup
Flash Point(C)
closed cup
Compare Similar Items
Show Difference
product name: Leptomycin B solution from Streptomyces sp., ≥95% (HPLC), Supplied in methanol: water (7:3)
Quality Level: 300
Assay: ≥95% (HPLC)
storage condition: protect from light
antibiotic activity spectrum: fungi
Mode of action: protein synthesis | interferes
shipped in: dry ice
storage temp.: −20°C
SMILES string: CCC(\C=C\[C@@H]1OC(=O)C=C[C@@H]1C)=C\[C@H](C)C\C=C\C(C)=C\[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C\C(C)=C\C(O)=O
InChI: 1S/C33H48O6/c1-9-28(14-15-29-24(5)13-16-31(36)39-29)19-22(3)12-10-11-21(2)17-25(6)32(37)27(8)33(38)26(7)18-23(4)20-30(34)35/h10-11,13-17,19-20,22,24-27,29,33,38H,9,12,18H2,1-8H3,(H,34,35)/b11-10+,15-14+,21-17+,23-20+,28-19-/t22-,24+,25-,26+,27-,29+,33-/m1/s1
product name: __
Quality Level: __
Assay: __
storage condition: __
antibiotic activity spectrum: __
Mode of action: __
shipped in: __
storage temp.: __
SMILES string: __
InChI: __
product name: __
Quality Level: __
Assay: __
storage condition: __
antibiotic activity spectrum: __
Mode of action: __
shipped in: __
storage temp.: __
SMILES string: __
InChI: __
