MAK323
Nitric Oxide Synthase Inhibitor Screening Kit
sufficient for 100 colorimetric tests
Manufacturer: Sigma Aldrich
Synonym(S): NOS Inhibitor Screening Kit
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 KIT | MAK323-1-KIT | In Stock | ₹ 50,915.70 |
MAK323 - 1 KIT
In Stock
Quantity
1
Base Price: ₹ 50,915.70
GST (18%): ₹ 9,164.826
Total Price: ₹ 60,080.526
usage
sufficient for 100 colorimetric tests
application(s)
pharmaceutical
detection method
colorimetric
relevant disease(s)
cardiovascular diseases
storage temp.
−20°C
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Description
- General description: Nitric oxide (NO) is a highly reactive radical that plays a crucial role in numerous essential physiological functions. It is produced by the oxidation of arginine through nitric oxide synthase (NOS), and it actively participates in various processes, including host defense, activation of regulatory proteins, and direct covalent interactions with functional biomolecules. Inhibition of NOS can have diverse biological effects, particularly within the cardiovascular system. Simple, direct and non-radioactive procedures for measuring NOS are becoming popular in drug discovery, biomedical and biochemical research.
- Application: The Nitric Oxide Synthase Screening Kit may be used for:Drug DiscoveryCardiovascular ResearchImmunology Research
- Biochem/physiol Actions: The mechanism of action for the Nitric Oxide Synthase Inhibitor Screening Kit comprises two steps:NOS Reaction Step: In this step, nitric oxide (NO) is produced through the activity of nitric oxide synthase (NOS).NO Detection Step: Following NO generation, the produced NO undergoes rapid oxidation to form nitrite and nitrate. The measurement of NO production is then conducted by quantifying the reduction of nitrate to nitrite, employing an enhanced Griess method.
- Features and Benefits: Efficient Inhibitor Screening: Screen for NOS inhibitors with only 5 µL of test compound, offering a streamlined and effortless procedure.High-Throughput Compatibility: Seamlessly integrate our kit into high-throughput handling systems, enhancing efficiency and accuracy in screening processes.
- Suitability: Suitable for inhibitor screening and evaluation of nitric oxide synthase inhibitors.
- Principle: The Nitric Oxide Synthase Inhibitor Screening Kit involves two steps: a NOS reaction step during which NO is produced followed by an NO detection step. Since the NO generated by NOS is rapidly oxidized to nitrite and nitrate, the NO production is measured following reduction of nitrate to nitrite using an improved Griess method.
- Other Notes: For additional information on our range of Biochemicals, please complete this form.
SAFETY INFORMATION
Pictograms
Signal Word
Warning
Hazard Statements
Precautionary Statements
P234 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2
WGK
WGK 3
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