P9386

Poly-L-histidine

mol wt 5,000-25,000

Manufacturer: Sigma Aldrich

CAS Number: 26062-48-6

Synonym(S): L-Histidine homopolymer

Select a Size

Pack Size SKU Availability Price
10 MG P9386-10-MG In Stock ₹ 14,685.30
50 MG P9386-50-MG In Stock ₹ 37,551.30
100 MG P9386-100-MG In Stock ₹ 69,907.80

P9386 - 10 MG

₹ 14,685.30

In Stock

Quantity

1

Base Price: ₹ 14,685.30

GST (18%): ₹ 2,643.354

Total Price: ₹ 17,328.654

form

powder or solid

Quality Level

200

mol wt

5,000-25,000

color

white to light yellow

application(s)

cell analysis

storage temp.

−20°C

InChI

1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1

InChI key

HNDVDQJCIGZPNO-YFKPBYRVSA-N

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Description

  • General description: Poly-L-histidine is an amphoteric compound. The imidazole ring in its structure enables protonation−deprotonation.[1]
  • Application: Poly-L-histidine has been used:as a polycation for the dispersion of multi-wall carbon nanotubes (MWCNTs)[2]as a polyionic compound to investigate its ability to rupture extracellular enveloped virus membrane[3]in screening its anti-prion activity in cell based and in vivo anti-prion assay[4]
  • Biochem/physiol Actions: Poly-L-histidine (Phis) copolymers are biocompatible, pH responsive and are less toxic. It exhibits endolysosomal escape funcationality. The copolymer of Phis with poly(ethylene glycol)−poly(d,l-lactide) (PEG-PLA) is effective in delivering doxorubicin.[5] pH sensitive poly(l-histidine) copolymer micelles have application in delivering anticancer drugs in acidic microenvironment.[6]
  • Analysis Note: Molecular weight by MALLS.
  • Other Notes: For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

SAFETY INFORMATION

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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−20°C

InChI:
1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1

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HNDVDQJCIGZPNO-YFKPBYRVSA-N

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1S/C17H27NO3.ClH/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18;/h5-8H,2-4,9-15H2,1H3;1H

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SYCBXBCPLUFJID-UHFFFAOYSA-N

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1S/2K.H2O4S/c;;1-5(2,3)4/h;;(H2,1,2,3,4)/q2*+1;/p-2

InChI key:
__