Description

• General description: This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
• Application: α-Hederin as a potent inhibitor in cancer research: α-Hederin has been identified and validated as a potent inhibitor of the Wnt/β-catenin signaling pathway in breast cancer stem cells, offering a promising avenue for targeted cancer therapy and highlighting its role in anti-cancer pharmacological research (Saliu et al., 2024). α-Hederin in overcoming drug resistance: This natural triterpenoid saponin has shown efficacy in reprogramming miRNA activity to overcome paclitaxel resistance mediated by small extracellular vesicles in non-small cell lung cancer (NSCLC), reinforcing its potential as a valuable agent in respiratory research and cancer treatment (Chang et al., 2024). α-Hederin′s role in promoting ferroptosis in cancer: Research indicates that α-Hederin can induce ferroptosis and reverse chemoresistance to cisplatin in non-small cell lung cancer, providing insights into its mechanism as a cytotoxic agent and its applications in enhancing the efficacy of conventional chemotherapies (Han et al., 2024). Molecular mechanisms of α-Hederin in tumor progression: A review of the molecular mechanisms by which α-Hederin influences tumor progression highlights its potential uses in biochemistry and pharmaceutical research, particularly for its anti-inflammatory and anticancer properties (Meng et al., 2024).
• Other Notes: This compound is commonly found in plants of the genus: hedera
• Legal Information: phyproof is a registered trademark of PhytoLab GmbH & Co. KG