R4643
9-cis-Retinoic acid
≥98% (HPLC)
Manufacturer: Sigma Aldrich
CAS Number: 5300-03-8
Synonym(S): 9-cis-Tretinoin, Alitretinoin
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 MG | R4643-1-MG | In Stock | ₹ 11,344.60 |
R4643 - 1 MG
In Stock
Quantity
1
Base Price: ₹ 11,344.60
GST (18%): ₹ 2,042.028
Total Price: ₹ 13,386.628
biological source
natural
Quality Level
200
Assay
≥98% (HPLC)
form
powder
technique(s)
HPLC: suitable
color
light yellow to yellow-orange
mp
189-190 °C
storage temp.
−20°C
SMILES string
CC1=C(\C=C\C(C)=C/C=C/C(C)=C/C(O)=O)C(C)(C)CCC1
InChI
1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+
Related Products
Description
- Application: 9-cis-Retinoic acid has been used:as ligand for retinoid X receptor gamma (RXRγ) for inducing oligodendrocyte precursor cells differentiation and remyelination[1]as a medium component to study its effect on UDP-glucuronosyltransferases (UGT) expression in thyroid induced hepatocytes[2]to induce lymphangiogenesis in lymphatic endothelial cell[3]
- Biochem/physiol Actions: 9-cis-Retinoic acid (9cRA) is an isomer of all-trans-retinoic acid (ATRA), both of which are lipid molecules synthesized from a common precursor, vitamin A.[4] 9cRA is a potent agonist for retinoid X receptor (RXR) and retinoic acid receptor (RAR).[5] It has neurotrophic functionality, promotes neuronal differentiation and may have therapeutic potential in treating stroke.[6] It also regulates cytokine secretion and lymphocyte proliferation.[4] 9cRA favors the dopamine cells survival and induces neuroprotection in neurodegenerative disorder like parkinson′s disease.[7] It elicits anti-inflammatory function and stimulates mast cells and inhibits interleukin 4 and 5 expression levels.[8] 9cRA is in clinical trial phase II for treating refractory cancer.[5]
- Features and Benefits: This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
- Packaging: Sealed ampule
SAFETY INFORMATION
Pictograms
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Compare Similar Items
Show Difference
biological source: natural
Quality Level: 200
Assay: ≥98% (HPLC)
form: powder
technique(s): HPLC: suitable
color: light yellow to yellow-orange
mp: 189-190 °C
storage temp.: −20°C
SMILES string: CC1=C(\C=C\C(C)=C/C=C/C(C)=C/C(O)=O)C(C)(C)CCC1
InChI: 1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+
biological source:
natural
Quality Level:
200
Assay:
≥98% (HPLC)
form:
powder
technique(s):
HPLC: suitable
color:
light yellow to yellow-orange
mp:
189-190 °C
storage temp.:
−20°C
SMILES string:
CC1=C(\C=C\C(C)=C/C=C/C(C)=C/C(O)=O)C(C)(C)CCC1
InChI:
1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+
biological source: synthetic (organic)
Quality Level: 200
Assay: ≥95% (HPLC)
form: powder
technique(s): tissue culture: suitable
color: __
mp: __
storage temp.: 2-8°C
SMILES string: __
InChI: 1S/C98H174N34O30/c1-48(2)31-60(84(151)120-56(79(100)146)22-17-27-107-96(101)102)124-86(153)62(33-50(5)6)126-88(155)64(35-52(9)10)128-89(156)65(36-53(11)12)127-87(154)63(34-51(7)8)125-85(152)61(32-49(3)4)123-83(150)59(24-19-29-109-98(105)106)122-91(158)67(44-133)119-76(142)42-113-73(139)39-111-72(138)38-112-74(140)40-114-82(149)58(21-15-16-26-99)121-92(159)69(46-135)130-93(160)68(45-134)129-80(147)54(13)116-94(161)71-25-20-30-132(71)95(162)70(47-136)131-90(157)66(37-78(144)145)118-77(143)43-115-81(148)57(23-18-28-108-97(103)104)117-75(141)41-110-55(14)137/h48-54,56-71,133-136H,15-47,99H2,1-14H3,(H2,100,146)(H,110,137)(H,111,138)(H,112,140)(H,113,139)(H,114,149)(H,115,148)(H,116,161)(H,117,141)(H,118,143)(H,119,142)(H,120,151)(H,121,159)(H,122,158)(H,123,150)(H,124,153)(H,125,152)(H,126,155)(H,127,154)(H,128,156)(H,129,147)(H,130,160)(H,131,157)(H,144,145)(H4,101,102,107)(H4,103,104,108)(H4,105,106,109)/t54-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-/m0/s1
biological source:
synthetic (organic)
Quality Level:
200
Assay:
≥95% (HPLC)
form:
powder
technique(s):
tissue culture: suitable
color:
__
mp:
__
storage temp.:
2-8°C
SMILES string:
__
InChI:
1S/C98H174N34O30/c1-48(2)31-60(84(151)120-56(79(100)146)22-17-27-107-96(101)102)124-86(153)62(33-50(5)6)126-88(155)64(35-52(9)10)128-89(156)65(36-53(11)12)127-87(154)63(34-51(7)8)125-85(152)61(32-49(3)4)123-83(150)59(24-19-29-109-98(105)106)122-91(158)67(44-133)119-76(142)42-113-73(139)39-111-72(138)38-112-74(140)40-114-82(149)58(21-15-16-26-99)121-92(159)69(46-135)130-93(160)68(45-134)129-80(147)54(13)116-94(161)71-25-20-30-132(71)95(162)70(47-136)131-90(157)66(37-78(144)145)118-77(143)43-115-81(148)57(23-18-28-108-97(103)104)117-75(141)41-110-55(14)137/h48-54,56-71,133-136H,15-47,99H2,1-14H3,(H2,100,146)(H,110,137)(H,111,138)(H,112,140)(H,113,139)(H,114,149)(H,115,148)(H,116,161)(H,117,141)(H,118,143)(H,119,142)(H,120,151)(H,121,159)(H,122,158)(H,123,150)(H,124,153)(H,125,152)(H,126,155)(H,127,154)(H,128,156)(H,129,147)(H,130,160)(H,131,157)(H,144,145)(H4,101,102,107)(H4,103,104,108)(H4,105,106,109)/t54-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-/m0/s1
biological source: __
Quality Level: 200
Assay: __
form: __
technique(s): __
color: red
mp: __
storage temp.: −20°C
SMILES string: __
InChI: __
biological source:
__
Quality Level:
200
Assay:
__
form:
__
technique(s):
__
color:
red
mp:
__
storage temp.:
−20°C
SMILES string:
__
InChI:
__
biological source: rat bone marrow (Rat bone marrow)
Quality Level: 100
Assay: __
form: __
technique(s): cell culture | mammalian: suitable
color: __
mp: __
storage temp.: −196°C
SMILES string: __
InChI: __
biological source:
rat bone marrow (Rat bone marrow)
Quality Level:
100
Assay:
__
form:
__
technique(s):
cell culture | mammalian: suitable
color:
__
mp:
__
storage temp.:
−196°C
SMILES string:
__
InChI:
__