Description

• General description: Propylphosphonic anhydride (T3P) is a reactive n-propyl phosphonic acid cyclic anhydride.[1] It is a mild and low toxic coupling agent used in peptide synthesis.[2] T3P also acts as a promoter and water scavenger in the Friedländer annulation reaction.[3] It participates in the conversion of carboxylic acids and amides into nitriles, formation of Weinreb amides, ester synthesis, dehydrations, oxidation of alcohols, isonitrile synthesis, synthesis of alkenes from alcohols and C-C coupling reactions.[1] T3P delivers outstanding advantages over traditional reagents, such as broad functional group tolerance, low epimerization, and water-soluble by-products and hence gives high purity and yield of the product.[4][1]
• Application: Propylphosphonic anhydride (T3P) can be used:As an acid-amine coupling reagent for the synthesis of 3-(trifluoromethyl)-1H-pyrazole-5-carboxamides which are potent activators of pyruvate kinase M2 (PKM2).[5]In the synthesis of substituted benzofurans as potent DNA gyraseB inhibitors of Mycobacterium tuberculosis.[6]As a catalyst in the synthesis of benzothiazoles, benzoxazoles, and benzimidazoles under microwave irradiation.[7]As a catalyst in the conversion of ketoximes to amides and aldoximes to nitriles via Beckmann rearrangement.[8]As a reagent in the one-pot conversion of aromatic, heteroaromatic, and aliphatic aldehydes to nitriles.[9]
• Legal Information: T3P is a registered trademark of Archimica GmbH