761524

Dibenzocyclooctyne-N-hydroxysuccinimidyl ester

for Copper-free Click Chemistry

Manufacturer: Sigma Aldrich

Synonym(S): DBCO-NHS ester, DBCO-SE

Select a Size

Pack Size SKU Availability Price
5 MG 761524-5-MG In Stock ₹ 7,783.18
50 MG 761524-50-MG In Stock ₹ 29,444.00

761524 - 5 MG

₹ 7,783.18

In Stock

Quantity

1

Base Price: ₹ 7,783.18

GST (18%): ₹ 1,400.972

Total Price: ₹ 9,184.152

Quality Level

100

form

solid

reaction suitability

reaction type: click chemistryreagent type: cross-linking reagent

mp

149-157 (decomposition)

functional group

NHS ester

storage temp.

−20°C

SMILES string

O=C(CCC(ON(C(CC1)=O)C1=O)=O)N2CC3=C(C=CC=C3)C#CC4=C2C=CC=C4

InChI

1S/C23H18N2O5/c26-20(13-14-23(29)30-25-21(27)11-12-22(25)28)24-15-18-7-2-1-5-16(18)9-10-17-6-3-4-8-19(17)24/h1-8H,11-15H2

InChI key

XCEBOJWFQSQZKR-UHFFFAOYSA-N

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Description

  • General description: DBCO-NHS ester is commonly used in bioconjugation. It consists of an NHS ester that reacts with primary amines on biomolecules and an alkyne group that allows for a specific reaction with molecules containing azides. This reaction is carried out through a copper-free click chemistry process called strain-promoted alkyne-azide cycloaddition.[1]
  • Application: Dibenzocyclooctyne-N-hydroxysuccinimidyl ester is commonly used:In the modification and labeling of biomolecules such as antibodies and streptavidin by introducing DBCO groups onto their surfaces[2] As a cross linker to conjugate peptide antigens onto the surface of poly(lactic-co-glycolic acid) (PLGA) nanoparticles[3]

SAFETY INFORMATION

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Compare Similar Items

Show Difference

Img

Sigma Aldrich

761524

for Copper-free Click Chemistry...


Quality Level:
100

form:
solid

reaction suitability:
reaction type: click chemistryreagent type: cross-linking reagent

mp:
149-157 (decomposition)

functional group:
NHS ester

storage temp.:
−20°C

SMILES string:
O=C(CCC(ON(C(CC1)=O)C1=O)=O)N2CC3=C(C=CC=C3)C#CC4=C2C=CC=C4

InChI:
1S/C23H18N2O5/c26-20(13-14-23(29)30-25-21(27)11-12-22(25)28)24-15-18-7-2-1-5-16(18)9-10-17-6-3-4-8-19(17)24/h1-8H,11-15H2

InChI key:
XCEBOJWFQSQZKR-UHFFFAOYSA-N

Img

Sigma Aldrich

761540

for Copper-free Click Chemistry...


Quality Level:
100

form:
solid

reaction suitability:
reaction type: click chemistryreagent type: linker

mp:
86-96 °C

functional group:
amine

storage temp.:
−20°C

SMILES string:
NCCC(N1CC2=C(C=CC=C2)C#CC3=C1C=CC=C3)=O

InChI:
1S/C18H16N2O/c19-12-11-18(21)20-13-16-7-2-1-5-14(16)9-10-15-6-3-4-8-17(15)20/h1-8H,11-13,19H2

InChI key:
OCCYFTDHSHTFER-UHFFFAOYSA-N

Img

Sigma Aldrich

76157

≥98.0% (TLC)...


Quality Level:
100

form:
powder

reaction suitability:
__

mp:
171 °C

functional group:
__

storage temp.:
−20°C

SMILES string:
N[C@@H](C[C@@H](O)C(O)=O)C(O)=O

InChI:
1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/t2-,3+/m0/s1

InChI key:
HBDWQSHEVMSFGY-STHAYSLISA-N

Img

Sigma Aldrich

76157

≥98.0% (TLC)...


Quality Level:
100

form:
powder

reaction suitability:
__

mp:
171 °C

functional group:
__

storage temp.:
−20°C

SMILES string:
N[C@@H](C[C@@H](O)C(O)=O)C(O)=O

InChI:
1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/t2-,3+/m0/s1

InChI key:
__