Description

• General description: SBAP is a sulfhydryl-reactive and amine-reactive heterobifunctional crosslinker. The reagent′s NHS ester reacts with primary amines at pH 7-9 to form stable amide bonds, and the bromacetyl reacts with sulfhydryl groups at pH >7.5 to form stable thioether bonds This reagent is useful for preparing cyclic peptides and peptide conjugates because the spacer maintains peptide-like character in the crosslinked species.
• Features and Benefits: Reactive groups: NHS ester and bromoacetylReactive toward: amino and sulfhydryl groupsNHS ester reacts with primary amines at pH 7-9 to form a stable amide bondBromacetyl group reacts with sulfhydryl groups at pH > 7.5 to form stable thioether bondsNon-cleavableWater-insoluble (dissolve first in DMF or DMSO)Spacer maintains peptide-like character in the crosslinked speciesResulting crosslink is susceptible to acid hydrolysisUseful for preparing cyclic peptides and peptide conjugates
• Caution: This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.