901490

(S,R,S)-AHPC hydrochloride

≥97%

Manufacturer: Sigma Aldrich

CAS Number: 1448189-80-7

Synonym(S): (2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride, E3 Ligase ligand, Ligand for PROTAC® research, VH032

Select a Size

Pack Size SKU Availability Price
100 MG 901490-100-MG In Stock ₹ 34,590.00

901490 - 100 MG

₹ 34,590.00

In Stock

Quantity

1

Base Price: ₹ 34,590.00

GST (18%): ₹ 6,226.20

Total Price: ₹ 40,816.20

ligand

VH032

Quality Level

100

Assay

≥97%

form

powder or crystals

reaction suitability

reagent type: ligand

storage temp.

2-8°C

SMILES string

N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C.Cl

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Description

  • Application: (S,R,S)-AHPC (HCl salt) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This (S,R,S) conformation is the active variant, and (S,S,S) is the inactive derivative (cat#901487) used as a negative control.
  • Other Notes: Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationPortal: Building PROTAC® Degraders for Targeted Protein DegradationStructure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar AffinitiesModular PROTAC Design for the DegradationofOncogenic BCR-ABLSelective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)
  • Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

SAFETY INFORMATION

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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ligand:
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Assay:
≥97%

form:
powder or crystals

reaction suitability:
reagent type: ligand

storage temp.:
2-8°C

SMILES string:
N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C.Cl

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Assay:
≥95%

form:
powder or crystals

reaction suitability:
reactivity: carboxyl reactivereagent type: ligand-linker conjugate

storage temp.:
2-8°C

SMILES string:
O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(COCCN)=O)=O.Cl

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O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3N)=O)N(C)C1=O

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Sigma Aldrich

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ligand:
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Quality Level:
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Assay:
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form:
powder or crystals

reaction suitability:
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SMILES string:
O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCOCCN)=O)=O)NC1=O.Cl