901490
(S,R,S)-AHPC hydrochloride
≥97%
Manufacturer: Sigma Aldrich
CAS Number: 1448189-80-7
Synonym(S): (2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride, E3 Ligase ligand, Ligand for PROTAC® research, VH032
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 100 MG | 901490-100-MG | In Stock | ₹ 34,590.00 |
901490 - 100 MG
In Stock
Quantity
1
Base Price: ₹ 34,590.00
GST (18%): ₹ 6,226.20
Total Price: ₹ 40,816.20
ligand
VH032
Quality Level
100
Assay
≥97%
form
powder or crystals
reaction suitability
reagent type: ligand
storage temp.
2-8°C
SMILES string
N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C.Cl
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Medchemexpress LLC HY-101763A 1g Medchemexpress, (S,R,S)-AHPC (hydrochloride) CAS:1448189-80-7 Purity:>98% | Medchemexpress LLC | ₹ 43,122.24 | |
| | Medchemexpress LLC HY-101763A 500mg Medchemexpress, (S,R,S)-AHPC (hydrochloride) CAS:1448189-80-7 Purity:>98% | Medchemexpress LLC | ₹ 26,951.40 | |
 | eMolecules Ambeed / (2S4R)-1-((S)-2-Amino-33-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride / 1mg / 724427129 / A113059 / / 1448189-80-7 / MFCD30502992 / 467.030 / C22H31ClN4O3S | eMolecules | ₹ 1,978.15 | |
 | (2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N- (4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride | Aaron Chemicals LLC | ₹ 684.48 - ₹ 59,293.08 | |
 | (S,R,S)-AHPC (monohydrochloride) | ChemScene | ₹ 3,422.40 - ₹ 1,62,564.00 |
Related Products
Description
- Application: (S,R,S)-AHPC (HCl salt) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This (S,R,S) conformation is the active variant, and (S,S,S) is the inactive derivative (cat#901487) used as a negative control.
- Other Notes: Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationPortal: Building PROTAC® Degraders for Targeted Protein DegradationStructure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar AffinitiesModular PROTAC Design for the DegradationofOncogenic BCR-ABLSelective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)
- Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Compare Similar Items
Show Difference
ligand: VH032
Quality Level: 100
Assay: ≥97%
form: powder or crystals
reaction suitability: reagent type: ligand
storage temp.: 2-8°C
SMILES string: N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C.Cl
ligand:
VH032
Quality Level:
100
Assay:
≥97%
form:
powder or crystals
reaction suitability:
reagent type: ligand
storage temp.:
2-8°C
SMILES string:
N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C.Cl
ligand: VH032
Quality Level: 100
Assay: ≥95%
form: powder or crystals
reaction suitability: reactivity: carboxyl reactivereagent type: ligand-linker conjugate
storage temp.: 2-8°C
SMILES string: O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(COCCN)=O)=O.Cl
ligand:
VH032
Quality Level:
100
Assay:
≥95%
form:
powder or crystals
reaction suitability:
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
storage temp.:
2-8°C
SMILES string:
O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(COCCN)=O)=O.Cl
ligand: N-Methylated Pomalidomide
Quality Level: 100
Assay: ≥98%
form: powder or crystals
reaction suitability: reagent type: ligand
storage temp.: 2-8°C
SMILES string: O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3N)=O)N(C)C1=O
ligand:
N-Methylated Pomalidomide
Quality Level:
100
Assay:
≥98%
form:
powder or crystals
reaction suitability:
reagent type: ligand
storage temp.:
2-8°C
SMILES string:
O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3N)=O)N(C)C1=O
ligand: pomalidomide
Quality Level: 100
Assay: ≥95%
form: powder or crystals
reaction suitability: reactivity: carboxyl reactivereagent type: ligand-linker conjugate
storage temp.: 2-8°C
SMILES string: O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCOCCN)=O)=O)NC1=O.Cl
ligand:
pomalidomide
Quality Level:
100
Assay:
≥95%
form:
powder or crystals
reaction suitability:
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
storage temp.:
2-8°C
SMILES string:
O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCOCCN)=O)=O)NC1=O.Cl