917419
2-(2-(Piperidin-4-yl)phenyl)ethan-1-amine dihydrochloride
Manufacturer: Sigma Aldrich
Synonym(S): Semi-flexible linker for PROTAC® development
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 100 MG | 917419-100-MG | In Stock | ₹ 53,042.50 |
917419 - 100 MG
In Stock
Quantity
1
Base Price: ₹ 53,042.50
GST (18%): ₹ 9,547.65
Total Price: ₹ 62,590.15
form
powder
Quality Level
100
reaction suitability
reagent type: linker
functional group
amine
storage temp.
2-8°C
SMILES string
NCCC1=C(C=CC=C1)C2CCNCC2.Cl.Cl
Related Products
Description
- Application: 2-(2-(Piperidin-4-yl)phenyl)ethan-1-amine dihydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.
- Other Notes: Portal: Building PROTAC® Degraders for Targeted Protein DegradationCrosslinkers for BioconjugationTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
- Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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form: powder
Quality Level: 100
reaction suitability: reagent type: linker
functional group: amine
storage temp.: 2-8°C
SMILES string: NCCC1=C(C=CC=C1)C2CCNCC2.Cl.Cl
form:
powder
Quality Level:
100
reaction suitability:
reagent type: linker
functional group:
amine
storage temp.:
2-8°C
SMILES string:
NCCC1=C(C=CC=C1)C2CCNCC2.Cl.Cl
form: powder
Quality Level: 100
reaction suitability: reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group: amine
storage temp.: 2-8°C
SMILES string: C[C@H](NCCCCCCN)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(OCC)=O)CC2=CC=C(C=C2)F)=O)=O)C(C)(C)C)=O.Cl
form:
powder
Quality Level:
100
reaction suitability:
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group:
amine
storage temp.:
2-8°C
SMILES string:
C[C@H](NCCCCCCN)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(OCC)=O)CC2=CC=C(C=C2)F)=O)=O)C(C)(C)C)=O.Cl
form: powder
Quality Level: 100
reaction suitability: reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group: amine
storage temp.: 2-8°C
SMILES string: C[C@H](NC(OC(C)(C)C)=O)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(OCCOCCN)=O)CC2=CC=C(C=C2)F)=O)=O)C(C)(C)C)=O.Cl
form:
powder
Quality Level:
100
reaction suitability:
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group:
amine
storage temp.:
2-8°C
SMILES string:
C[C@H](NC(OC(C)(C)C)=O)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(OCCOCCN)=O)CC2=CC=C(C=C2)F)=O)=O)C(C)(C)C)=O.Cl
form: powder
Quality Level: 100
reaction suitability: reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group: amine
storage temp.: 2-8°C
SMILES string: C[C@H](NC(OC(C)(C)C)=O)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(NCCCCCCN)=O)CC2=CC=C(C=C2)F)=O)=O)C3CCCCC3)=O
form:
powder
Quality Level:
100
reaction suitability:
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group:
amine
storage temp.:
2-8°C
SMILES string:
C[C@H](NC(OC(C)(C)C)=O)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(NCCCCCCN)=O)CC2=CC=C(C=C2)F)=O)=O)C3CCCCC3)=O