920665
2-(1-(1-(tert-Butoxycarbonyl)piperidin-3-yl)-1H-pyrazol-4-yl)acetic acid
Manufacturer: Sigma Aldrich
CAS Number: 1781095-18-8
Synonym(S): Rigid linker for PROTAC® development
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 50 MG | 920665-50-MG | In Stock | ₹ 31,013.63 |
| 100 MG | 920665-100-MG | In Stock | ₹ 54,298.20 |
920665 - 50 MG
In Stock
Quantity
1
Base Price: ₹ 31,013.63
GST (18%): ₹ 5,582.453
Total Price: ₹ 36,596.083
reaction suitability
reagent type: linker
Quality Level
100
functional group
Boccarboxylic acid
SMILES string
CC(C)(OC(N1CCCC(N2C=C(C=N2)CC(O)=O)C1)=O)C
Related Products
Description
- Application: 2-(1-(1-(tert-Butoxycarbonyl)piperidin-3-yl)-1H-pyrazol-4-yl)acetic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.Similar linkers in this series:920533 920649 920673 920703
- Other Notes: Portal: Building PROTAC® Degraders for Targeted Protein DegradationCrosslinkers for BioconjugationTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
- Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Compare Similar Items
Show Difference
reaction suitability: reagent type: linker
Quality Level: 100
functional group: Boccarboxylic acid
SMILES string: CC(C)(OC(N1CCCC(N2C=C(C=N2)CC(O)=O)C1)=O)C
reaction suitability:
reagent type: linker
Quality Level:
100
functional group:
Boccarboxylic acid
SMILES string:
CC(C)(OC(N1CCCC(N2C=C(C=N2)CC(O)=O)C1)=O)C
reaction suitability: __
Quality Level: __
functional group: __
SMILES string: __
reaction suitability:
__
Quality Level:
__
functional group:
__
SMILES string:
__
reaction suitability: __
Quality Level: __
functional group: __
SMILES string: __
reaction suitability:
__
Quality Level:
__
functional group:
__
SMILES string:
__
reaction suitability: __
Quality Level: __
functional group: __
SMILES string: __
reaction suitability:
__
Quality Level:
__
functional group:
__
SMILES string:
__