929344
(S,R,S)-AHPC-C5-phosphoramidite
Manufacturer: Sigma Aldrich
Synonym(S): (3R,5S)-1-((2S)-2-(6-(((2-Cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)hexanamido)-3,3-dimethylbutanoyl)-5-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-3-yl acetate
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 50 MG | 929344-50-MG | In Stock | ₹ 38,690.00 |
929344 - 50 MG
In Stock
Quantity
1
Base Price: ₹ 38,690.00
GST (18%): ₹ 6,964.20
Total Price: ₹ 45,654.20
ligand
VH032
Quality Level
100
form
solid or liquid
storage temp.
2-8°C
SMILES string
O=C(N1C[C@H](OC(C)=O)C[C@H]1C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)[C@H](C(C)(C)C)NC(CCCCCOP(OCCC#N)N(C(C)C)C(C)C)=O
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Description
- Application: Protein degrader building block (S,R,S)-AHPC-C5-phosphoramidite enables the synthesis of molecules for degradation of proteins and PROTAC® (proteolysis-targeting chimeras) research. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand, a rigid linker, and a pendant phosphoramidite for reactivity with target DNA-binding proteins such as transcription factors. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, parallel synthesis can be used to more quickly generate degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationProtein Degrader Building Blocks
- Other Notes: Targeted Protein Degradation by Small MoleculesDestruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERGSmall-Molecule PROTACS: New Approaches to Protein DegradationTargeted Protein Degradation: from Chemical Biology to Drug DiscoveryImpact of linker length on the activity of PROTACs
- Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Show Difference
ligand: VH032
Quality Level: 100
form: solid or liquid
storage temp.: 2-8°C
SMILES string: O=C(N1C[C@H](OC(C)=O)C[C@H]1C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)[C@H](C(C)(C)C)NC(CCCCCOP(OCCC#N)N(C(C)C)C(C)C)=O
ligand:
VH032
Quality Level:
100
form:
solid or liquid
storage temp.:
2-8°C
SMILES string:
O=C(N1C[C@H](OC(C)=O)C[C@H]1C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)[C@H](C(C)(C)C)NC(CCCCCOP(OCCC#N)N(C(C)C)C(C)C)=O
ligand: VH032
Quality Level: __
form: powder
storage temp.: 2-8°C
SMILES string: CC(C)(C)OC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)OC(OCC(C)(C)SS(C)(=O)=O)=O)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)=O)=O
ligand:
VH032
Quality Level:
__
form:
powder
storage temp.:
2-8°C
SMILES string:
CC(C)(C)OC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)OC(OCC(C)(C)SS(C)(=O)=O)=O)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)=O)=O
ligand: __
Quality Level: 100
form: __
storage temp.: __
SMILES string: __
ligand:
__
Quality Level:
100
form:
__
storage temp.:
__
SMILES string:
__
ligand: thalidomide
Quality Level: 100
form: powder
storage temp.: 2-8°C
SMILES string: COC1=CC(COC(N2C(CCC(N3C(C4=CC=CC(OCC(NCCCCN)=O)=C4C3=O)=O)C2=O)=O)=O)=C(C=C1OC)[N+]([O-])=O.Cl
ligand:
thalidomide
Quality Level:
100
form:
powder
storage temp.:
2-8°C
SMILES string:
COC1=CC(COC(N2C(CCC(N3C(C4=CC=CC(OCC(NCCCCN)=O)=C4C3=O)=O)C2=O)=O)=O)=C(C=C1OC)[N+]([O-])=O.Cl