929352
(S,R,S)-AHPC-di-trimethylamide-dioxodisulfide-carbonate ester
Manufacturer: Sigma Aldrich
CAS Number: 2417370-08-0
Synonym(S): S-(1-(((((3R,5S)-1-((S)-2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoyl)-5-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-3-yl)oxy)carbonyl)oxy)-2-methylpropan-2-yl) methanesulfonothioate
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 50 MG | 929352-50-MG | In Stock | ₹ 40,530.00 |
929352 - 50 MG
In Stock
Quantity
1
Base Price: ₹ 40,530.00
GST (18%): ₹ 7,295.40
Total Price: ₹ 47,825.40
ligand
VH032
Assay
≥95%
form
powder
functional group
disulfide
storage temp.
2-8°C
SMILES string
CC(C)(C)OC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)OC(OCC(C)(C)SS(C)(=O)=O)=O)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)=O)=O
Related Products
Description
- Application: Protein degrader building block (S,R,S)-AHPC-di-trimethylamide-dioxodisulfide-carbonate ester enables the synthesis of molecules for degradation of proteins and PROTAC® (proteolysis-targeting chimeras) research. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a pendant disulfide, linked via a carbonate group. The pendant disulfide allows for targeted degradation of antibodies. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, parallel synthesis can be used to more quickly generate degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation Protein Degrader Building Blocks
- Other Notes: Targeted Protein Degradation by Small Molecules Antibody Conjugation of a Chimeric BET Degrader Enables in vivo ActivitySmall-Molecule PROTACS: New Approaches to Protein DegradationTargeted Protein Degradation: from Chemical Biology to Drug Discovery Impact of linker length on the activity of PROTACs
- Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
SAFETY INFORMATION
WGK
WGK 3
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ligand: VH032
Assay: ≥95%
form: powder
functional group: disulfide
storage temp.: 2-8°C
SMILES string: CC(C)(C)OC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)OC(OCC(C)(C)SS(C)(=O)=O)=O)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)=O)=O
ligand:
VH032
Assay:
≥95%
form:
powder
functional group:
disulfide
storage temp.:
2-8°C
SMILES string:
CC(C)(C)OC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)OC(OCC(C)(C)SS(C)(=O)=O)=O)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)=O)=O
ligand: __
Assay: __
form: __
functional group: __
storage temp.: __
SMILES string: __
ligand:
__
Assay:
__
form:
__
functional group:
__
storage temp.:
__
SMILES string:
__
ligand: thalidomide
Assay: __
form: powder
functional group: amine
storage temp.: 2-8°C
SMILES string: COC1=CC(COC(N2C(CCC(N3C(C4=CC=CC(OCC(NCCCCN)=O)=C4C3=O)=O)C2=O)=O)=O)=C(C=C1OC)[N+]([O-])=O.Cl
ligand:
thalidomide
Assay:
__
form:
powder
functional group:
amine
storage temp.:
2-8°C
SMILES string:
COC1=CC(COC(N2C(CCC(N3C(C4=CC=CC(OCC(NCCCCN)=O)=C4C3=O)=O)C2=O)=O)=O)=C(C=C1OC)[N+]([O-])=O.Cl
ligand: pomalidomide
Assay: __
form: solid or liquid
functional group: __
storage temp.: 2-8°C
SMILES string: O=C1C2=C(C(NCCOCCOCCOP(N(C(C)C)C(C)C)OCCC#N)=CC=C2)C(N1C3C(NC(CC3)=O)=O)=O
ligand:
pomalidomide
Assay:
__
form:
solid or liquid
functional group:
__
storage temp.:
2-8°C
SMILES string:
O=C1C2=C(C(NCCOCCOCCOP(N(C(C)C)C(C)C)OCCC#N)=CC=C2)C(N1C3C(NC(CC3)=O)=O)=O