917478

BocA1V1PF2

≥95%

Manufacturer: Sigma Aldrich

Synonym(S): (S)-2-((S)-1-((S)-2-((S)-2-((tert-Butoxycarbonyl)amino)propanamido)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-3-(4-fluorophenyl)propanoic acid, AVP ligand, IAP E3 ligase lead for protein degrader research, SNIPER building block

Select a Size

Pack Size SKU Availability Price
100 MG 917478-100-MG In Stock ₹ 49,546.03

917478 - 100 MG

₹ 49,546.03

In Stock

Quantity

1

Base Price: ₹ 49,546.03

GST (18%): ₹ 8,918.285

Total Price: ₹ 58,464.315

ligand

BocA1V1PF2

Quality Level

100

Assay

≥95%

form

powder

reaction suitability

reagent type: ligand

functional group

carboxylic acid

storage temp.

2-8°C

SMILES string

C[C@H](NC(OC(C)(C)C)=O)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(O)=O)CC2=CC=C(C=C2)F)=O)=O)C(C)(C)C)=O

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Description

  • Application: BocA1V1PF2 is an in silico-derived inhibitor of apoptosis protein (IAP)-recruiting ligand for targeted protein degradation and SNIPER (specific and non-genetic IAP-dependent protein erasers) development, launched in partnership with ComInnex. Learn more about the novel IAP ligands generated through virtual screening of AVP mimetics in our Technology Spotlight. A C-terminal variant of BocA1V1PF2 is also available as A1V1PF2-OEt (917710).BocA1V1PF2 conjugates are also available for degrader synthesis. Browse our full synthesis offering here for streamlining SNIPER and PROTAC® degrader libraries: Degrader Building Blocks916927 BocA1V1PF2-OC6-NH2 hydrochloride917184 BocA1V1PF2-OC10-NH2 hydrochloride917435 BocA1V1PF2-OPEG1-NH2 hydrochloride917680 BocA1V1PF2-OPEG3-NH2 hydrochlorideTechnology Spotlight: Degrader Building Blocks with Inhibitor of Apoptosis Protein (IAP) In Silico-Derived Ligands
  • Other Notes: In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)SNIPERs−Hijacking IAP activity to induce protein degradationE3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones
  • Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

SAFETY INFORMATION

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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ligand:
BocA1V1PF2

Quality Level:
100

Assay:
≥95%

form:
powder

reaction suitability:
reagent type: ligand

functional group:
carboxylic acid

storage temp.:
2-8°C

SMILES string:
C[C@H](NC(OC(C)(C)C)=O)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(O)=O)CC2=CC=C(C=C2)F)=O)=O)C(C)(C)C)=O

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Sigma Aldrich

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≥95%

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powder

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SMILES string:
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ligand:
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reaction suitability:
reactivity: carboxyl reactivereagent type: ligand-linker conjugate

functional group:
amine

storage temp.:
2-8°C

SMILES string:
C[C@H](NCCCCCCCCCCN)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(OCC)=O)CC2=CC=C(C=C2)F)=O)=O)C(C)(C)C)=O.Cl