916714
A1V2PF2-NHEt
≥95%
Manufacturer: Sigma Aldrich
Synonym(S): (S)-1-((S)-2-((S)-2-Aminopropanamido)-2-cyclohexylacetyl)-N-((S)-1-(ethylamino)-3-(4-fluorophenyl)-1-oxopropan-2-yl)pyrrolidine-2-carboxamide, AVP ligand, IAP E3 ligase lead for protein degrader research, SNIPER building block
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 100 MG | 916714-100-MG | In Stock | ₹ 48,896.53 |
916714 - 100 MG
In Stock
Quantity
1
Base Price: ₹ 48,896.53
GST (18%): ₹ 8,801.375
Total Price: ₹ 57,697.905
ligand
A1V2PF2
Quality Level
100
Assay
≥95%
form
powder
reaction suitability
reagent type: ligand
functional group
amine
storage temp.
2-8°C
SMILES string
N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(NCC)=O)CC2=CC=C(C=C2)F)=O)=O)C3CCCCC3)=O)C
Related Products
Description
- Application: A1V2PF2-NHEt is an in silico-derived inhibitor of apoptosis protein (IAP)-recruiting ligand for targeted protein degradatio and SNIPER (specific and non-genetic IAP-dependent protein erasers) development, launched in partnership with ComInnex. Learn more about the novel IAP ligands generated through virtual screening of AVP mimetics in our Technology Spotlight. An N-terminal variant of A1V2PF2-NHEt is also available as BocA1V2PF2 (917974).A1V2PF2-NHEt conjugates are also available for degrader synthesis. Browse our full synthesis offering here for streamlining SNIPER and PROTAC® degrader libraries: Degrader Building Blocks with Inhibitor of Apoptosis Protein (IAP) In Silico-Derived Ligands917931 A1V2PF2-NHEt-C6-NH2916684 A1V2PF2-NHEt-C10-NH2916935 A1V2PF2-NHEt-PEG1-NH2917192 A1V2PF2-NHEt-PEG3-NH2
- Other Notes: Technology Spotlight: Degrader Building Blocks with Inhibitor of Apoptosis Protein (IAP) In Silico-Derived LigandsIn Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)SNIPERs−Hijacking IAP activity to induce protein degradationE3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones
- Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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ligand: A1V2PF2
Quality Level: 100
Assay: ≥95%
form: powder
reaction suitability: reagent type: ligand
functional group: amine
storage temp.: 2-8°C
SMILES string: N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(NCC)=O)CC2=CC=C(C=C2)F)=O)=O)C3CCCCC3)=O)C
ligand:
A1V2PF2
Quality Level:
100
Assay:
≥95%
form:
powder
reaction suitability:
reagent type: ligand
functional group:
amine
storage temp.:
2-8°C
SMILES string:
N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(NCC)=O)CC2=CC=C(C=C2)F)=O)=O)C3CCCCC3)=O)C
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100
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powder
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