917222
A1V2PF1-NHEt
≥95%
Manufacturer: Sigma Aldrich
Synonym(S): (S)-1-((S)-2-((S)-2-Aminopropanamido)-2-cyclohexylacetyl)-N-((S)-1-(ethylamino)-1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide, AVP ligand, IAP E3 ligase lead for protein degrader research, SNIPER building block
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 100 MG | 917222-100-MG | In Stock | ₹ 48,896.53 |
917222 - 100 MG
In Stock
Quantity
1
Base Price: ₹ 48,896.53
GST (18%): ₹ 8,801.375
Total Price: ₹ 57,697.905
ligand
A1V2PF1
Quality Level
100
Assay
≥95%
form
powder
reaction suitability
reagent type: ligand
functional group
amine
storage temp.
2-8°C
SMILES string
N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(NCC)=O)CC2=CC=CC=C2)=O)=O)C3CCCCC3)=O)C
Related Products
Description
- Application: A1V2PF1-NHEt is an in silico-derived inhibitor of apoptosis protein (IAP)-recruiting ligand for targeted protein degradation and SNIPER (specific and non-genetic IAP-dependent protein erasers) development, launched in partnership with ComInnex. Learn more about the novel IAP ligands generated through virtual screening of AVP mimetics in our Technology Spotlight. An N-terminal variant of A1V2PF1-NHEt is also available as BocA1V2PF1 (916978).A1V2PF1-NHEt conjugates are also available for degrader synthesis. Browse our full synthesis offering here for streamlining SNIPER and PROTAC® degrader libraries: Degrader Building Blocks916943 A1V2PF1-NHEt-C6-NH2917206 A1V2PF1-NHEt-C10-NH2917451 A1V2PF1-NHEt-PEG1-NH2917702 A1V2PF1-NHEt-PEG3-NH2Technology Spotlight: Degrader Building Blocks with Inhibitor of Apoptosis Protein (IAP) In Silico-Derived Ligands
- Other Notes: In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)SNIPERs−Hijacking IAP activity to induce protein degradationE3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones
- Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Compare Similar Items
Show Difference
ligand: A1V2PF1
Quality Level: 100
Assay: ≥95%
form: powder
reaction suitability: reagent type: ligand
functional group: amine
storage temp.: 2-8°C
SMILES string: N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(NCC)=O)CC2=CC=CC=C2)=O)=O)C3CCCCC3)=O)C
ligand:
A1V2PF1
Quality Level:
100
Assay:
≥95%
form:
powder
reaction suitability:
reagent type: ligand
functional group:
amine
storage temp.:
2-8°C
SMILES string:
N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(NCC)=O)CC2=CC=CC=C2)=O)=O)C3CCCCC3)=O)C
ligand: __
Quality Level: 100
Assay: __
form: __
reaction suitability: __
functional group: __
storage temp.: __
SMILES string: __
ligand:
__
Quality Level:
100
Assay:
__
form:
__
reaction suitability:
__
functional group:
__
storage temp.:
__
SMILES string:
__
ligand: __
Quality Level: 200
Assay: ≥99% (CP)
form: crystals
reaction suitability: __
functional group: __
storage temp.: __
SMILES string: [15NH4+].[Cl-]
ligand:
__
Quality Level:
200
Assay:
≥99% (CP)
form:
crystals
reaction suitability:
__
functional group:
__
storage temp.:
__
SMILES string:
[15NH4+].[Cl-]
ligand: __
Quality Level: 100
Assay: ≥95%
form: powder
reaction suitability: reagent type: linker
functional group: Boccarboxylic acid
storage temp.: 2-8°C
SMILES string: O=C(OC(C)(C)C)N1CCC(C2=CC=C(CC(O)=O)C=C2)CC1
ligand:
__
Quality Level:
100
Assay:
≥95%
form:
powder
reaction suitability:
reagent type: linker
functional group:
Boccarboxylic acid
storage temp.:
2-8°C
SMILES string:
O=C(OC(C)(C)C)N1CCC(C2=CC=C(CC(O)=O)C=C2)CC1