930237
2,5-dioxopyrrolidin-1-yl (2,5-dichlorobenzoyl)glycyl-L-leucinate
≥95%
Manufacturer: Sigma Aldrich
Synonym(S): CANDDY_MLN Tag NHS ester
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 250 MG | 930237-250-MG | In Stock | ₹ 15,761.20 |
930237 - 250 MG
In Stock
Quantity
1
Base Price: ₹ 15,761.20
GST (18%): ₹ 2,837.016
Total Price: ₹ 18,598.216
Quality Level
100
Assay
≥95%
form
powder
storage temp.
2-8°C
SMILES string
ClC1=CC=C(Cl)C(C(NCC(N[C@H](C(ON2C(CCC2=O)=O)=O)CC(C)C)=O)=O)=C1
Related Products
Description
- Application: CANDDY (Chemical knockdown with Affinity aNd Degradation DYnamics) employs a bispecific molecule (target interactor + linker + CANDDY_MLN) that degrades protein by direct recruitment to the proteasome. Shown to selectively and dose-dependently degrade KRAS G12D/V and MDM2 proteins and suppress their signaling without non-specific cytotoxic effects. CANDDY, a protein-slaying approach, occurs without ubiquitination and bypasses the need for an E3 ligase. Has the potential to overcome the current limitations of proteolysis and to expand the application scope of degraders.
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Quality Level: 100
Assay: ≥95%
form: powder
storage temp.: 2-8°C
SMILES string: ClC1=CC=C(Cl)C(C(NCC(N[C@H](C(ON2C(CCC2=O)=O)=O)CC(C)C)=O)=O)=C1
Quality Level:
100
Assay:
≥95%
form:
powder
storage temp.:
2-8°C
SMILES string:
ClC1=CC=C(Cl)C(C(NCC(N[C@H](C(ON2C(CCC2=O)=O)=O)CC(C)C)=O)=O)=C1
Quality Level: __
Assay: __
form: __
storage temp.: −20°C
SMILES string: [H]C1([H])C2OC3([H])OC=CC3(O)C1C4(C)OC24[C@@]5(C)[C@@H](O)[C@@H]6OC[C@]7([C@H](C[C@H](OC(=O)C(C)=CC)[C@]8(COC(O)([C@H]58)C(=O)OC)[C@@]67[H])OC(C)=O)C(=O)OC
Quality Level:
__
Assay:
__
form:
__
storage temp.:
−20°C
SMILES string:
[H]C1([H])C2OC3([H])OC=CC3(O)C1C4(C)OC24[C@@]5(C)[C@@H](O)[C@@H]6OC[C@]7([C@H](C[C@H](OC(=O)C(C)=CC)[C@]8(COC(O)([C@H]58)C(=O)OC)[C@@]67[H])OC(C)=O)C(=O)OC
Quality Level: __
Assay: __
form: __
storage temp.: __
SMILES string: __
Quality Level:
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Assay:
__
form:
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storage temp.:
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SMILES string:
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Quality Level: 100
Assay: __
form: viscous liquid (to powder)
storage temp.: −20°C
SMILES string: __
Quality Level:
100
Assay:
__
form:
viscous liquid (to powder)
storage temp.:
−20°C
SMILES string:
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