929484
FBnG-C3-PEG1-C3-NH2 hydrochloride
≥95%
Manufacturer: Sigma Aldrich
Synonym(S): (R)-2-acetamido-3-((2-amino-9-(4-fluorobenzyl)-6-oxo-6,9-dihydro-1H-purin-8-yl)thio)-N-(3-(3-aminopropoxy)propyl)propanamide hydrochloride
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 50 MG | 929484-50-MG | In Stock | ₹ 44,988.30 |
929484 - 50 MG
In Stock
Quantity
1
Base Price: ₹ 44,988.30
GST (18%): ₹ 8,097.894
Total Price: ₹ 53,086.194
Quality Level
100
Assay
≥95%
form
powder
functional group
amine
storage temp.
2-8°C
SMILES string
O=C1NC(N)=NC2=C1N=C(SC[C@@H](C(NCCCOCCCN)=O)NC(C)=O)N2CC3=CC=C(C=C3)F.Cl
Related Products
Description
- Application: Protein degrader building block FBnG-C3-PEG1-C3-NH2 hydrochloride enables the synthesis of molecules for degradation of proteins and PROTAC® (proteolysis-targeting chimeras) research. This conjugate contains a p-fluorobenzylguanine (FBnG) ligand, a PEG linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation Protein Degrader Building Blocks
- Other Notes: Targeted Protein Degradation by Small Molecules AUTACs: Cargo-Specific Degraders Using Selective Autophagy Small-Molecule PROTACS: New Approaches to Protein Degradation Targeted Protein Degradation: from Chemical Biology to Drug DiscoveryImpact of linker length on the activity of PROTACs
- Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Quality Level: 100
Assay: ≥95%
form: powder
functional group: amine
storage temp.: 2-8°C
SMILES string: O=C1NC(N)=NC2=C1N=C(SC[C@@H](C(NCCCOCCCN)=O)NC(C)=O)N2CC3=CC=C(C=C3)F.Cl
Quality Level:
100
Assay:
≥95%
form:
powder
functional group:
amine
storage temp.:
2-8°C
SMILES string:
O=C1NC(N)=NC2=C1N=C(SC[C@@H](C(NCCCOCCCN)=O)NC(C)=O)N2CC3=CC=C(C=C3)F.Cl
Quality Level: 100
Assay: __
form: liquid
functional group: __
storage temp.: 2-8°C
SMILES string: __
Quality Level:
100
Assay:
__
form:
liquid
functional group:
__
storage temp.:
2-8°C
SMILES string:
__
Quality Level: 100
Assay: ≥95%
form: powder, flakes, or chunks
functional group: __
storage temp.: __
SMILES string: CC(C)(CC(C)(C)C)N1C=[N+](C(C)(CC(C)(C)C)C)CC1.[Cl-]
Quality Level:
100
Assay:
≥95%
form:
powder, flakes, or chunks
functional group:
__
storage temp.:
__
SMILES string:
CC(C)(CC(C)(C)C)N1C=[N+](C(C)(CC(C)(C)C)C)CC1.[Cl-]
Quality Level: 100
Assay: ≥95%
form: powder
functional group: __
storage temp.: __
SMILES string: CC(C)(CC(C)(C)C)N1C=[N+](C(C)(CC(C)(C)C)C)C2=C1C=CC=C2.[Cl-]
Quality Level:
100
Assay:
≥95%
form:
powder
functional group:
__
storage temp.:
__
SMILES string:
CC(C)(CC(C)(C)C)N1C=[N+](C(C)(CC(C)(C)C)C)C2=C1C=CC=C2.[Cl-]