Anti-Parvalbumin Antibody, clone 4G3 , ZooMAb® Rabbit Monoclonal

Description

• General description: We are committed to bringing you greener alternative products, which adhere to one or more of The 12 Principles of Green Chemistry.This antibody is Preservative-free, produced without the harm or sacrifice of animals and exceptionally stable to allow for ambient shipping and storage if needed and thus aligns with "Waste Prevention", "Designing Safer Chemicals" and "Design for Energy Efficiency". Click here for more information.
• Specificity: Clone 4G3 is a ZooMAb rabbit recombinant monoclonal antibody that specifically detects Parvalbumin.
• Immunogen: GST/His-tagged full-length recombinant human Parvalbumin.
• Application: Anti-Parvalbumin, clone 4G3 ZooMAb, Cat. No. ZRB1218, is a highly specific rabbit recombinant monoclonal antibody that targets Parvalbumin and has been tested for use in Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Western Blotting.
• Target description: Parvalbumin alpha (UniProt: P20472; also known as PV) is encoded by the PVALB gene (Gene ID: 5816) in human. Parvalbumin is a low molecular weight soluble protein that binds two calcium ions with high affinity and is implicated in intracellular calcium regulation and trafficking. It is composed almost entirely of two EF-hand domains (aa. 39-74 & 78-110) and is structurally related to calmodulin and troponin C. It serves as a slow Ca2+ buffer that affects the amplitude and time course of intracellular Ca2+ transients in terminals after an action potential, and hence may regulate short-term synaptic plasticity. During nervous system development, its expression is shown to accompany the maturation of functional circuits. Parvalbumin containing neurons are abundant in the cortex, the hippocampus, and the thalamus. It is present in GABAergic interneurons in the nervous system, especially the reticular thalamus. Parvalbumin interneurons are a subset of inhibitory GABAergic neurons that control the excitability of post-synaptic pyramidal neurons. Dysfunction or loss of parvalbumin interneurons has been implicated in cognitive deficits associated with several well-known psychiatric disorders, including schizophrenia and depression. This ZooMAb recombinant monoclonal antibody, generated by our propriety technology, offers significantly enhanced specificity, affinity, reproducibility, and stability over conventional monoclonals.
• Physical form: Purified recombinant rabbit monoclonal antibody IgG, lyophilized in PBS with 5% Trehalose, normal appearance a coarse or translucent resin. Contains no biocide or preservatives, such as azide, or any animal by-products. Larger pack sizes provided as multiples of 25 μL.
• Reconstitution: 30 μg/mL after reconstitution at 25 μL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.
• Storage and Stability: Recommend storage of lyophilized product at 2-8°C; Before reconstitution, micro-centrifuge vials briefly to spin down material to bottom of the vial; Reconstitute each vial by adding 25 μL of filtered lab grade water or PBS; Reconstituted antibodies can be stored at 2-8°C, or -20°C for long term storage. Avoid repeated freeze-thaws.
• Legal Information: ZooMAb is a registered trademark of Merck KGaA, Darmstadt, Germany
• Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.