21-845-0

Tocris Bioscience™ SN-6

Manufacturer: Fischer Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 21-845-0-Each-of-1 In Stock ₹ 1,00,440.60

21-845-0 - Each of 1

₹ 1,00,440.60

In Stock

Quantity

1

Base Price: ₹ 1,00,440.60

GST (18%): ₹ 18,079.308

Total Price: ₹ 1,18,519.908

Purity

>99%

Product Type

SN-6

Inhibitors

SN-6

Quantity

50 mg

Molecular Weight (g/mol)

402.16

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Description

  • Selective Na+/Ca2+-exchange (NCX) inhibitor; displays some selectivity for NCX1
  • IC50 values are 2.9, 16 and 8.6 μM for inhibition of intracellular Na+-dependent 45Ca2+ uptake by cells expressing NCX1, NCX2 and NCX3 respectively
  • Has some affinity for mACh receptors (IC50 = 18 μM) but minimal activity against NCKX2 and various receptors and ion channels (IC50 > 30 μM)
  • Preferentially blocks Ca2+ influx mode and is more selective for NCX isoforms than KB-R7943 (Cat
  • No
  • 1244)
  • Anti-ischemic; potently protects against hypoxia-induced renal tubular cell damage (IC50 = 0.63 μM).

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