5546030
Tocris Bioscience™ SN-6
Selective Na+/Ca2+ exchange inhibitor (reverse mode)
Manufacturer: Fischer Scientific
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Purity
>99%
Product Type
SN-6
Molecular Weight (g/mol)
402.16
Inhibitors
SN-6
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Description
- Selective Na+/Ca2+-exchange (NCX) inhibitor; displays some selectivity for NCX1
- IC50 values are 2.9, 16 and 8.6 μM for inhibition of intracellular Na+-dependent 45Ca2+ uptake by cells expressing NCX1, NCX2 and NCX3 respectively
- Has some affinity for mACh receptors (IC50 = 18 μM) but minimal activity against NCKX2 and various receptors and ion channels (IC50 > 30 μM)
- Preferentially blocks Ca2+ influx mode and is more selective for NCX isoforms than KB-R7943 (Cat
- No
- 1244)
- Anti-ischemic; potently protects against hypoxia-induced renal tubular cell damage (IC50 = 0.63 μM).
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