5545712

Tocris Bioscience™ BIO 5192

Highly potent and selective inhibitor of integrin α4β1

Manufacturer: Fischer Scientific

The price for this product is unavailable. Please request a quote

Purity

>98%

Product Type

BIO 5192

Molecular Weight (g/mol)

817.78

Inhibitors

BIO 5192

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Description

  • Highly selective and potent inhibitor of integrin α4β1 (Very Late Antigen-4; VLA-4) (Kd < 10 pM)
  • Selectively binds α4β1 over a range of other integrins (IC50 values are 1.8, 138, 1053, > 500 and > 10,000 nM for α4β1, α9β1, α2β1, α4β7 and αIIbβ3, respectively)
  • Induces a 30-fold increase in mobilization of murine hematopoietic stem and progenitor cells; displays a 3-fold additive effect with AMD 3100 (Cat
  • No
  • 3299)
  • Decreases oxidative damage and improves neurological function following spinal cord injury in rats.

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