5545713
Tocris Bioscience™ BIRT 377
Potent negative allosteric modulator of LFA-1
Manufacturer: Fischer Scientific
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Purity
>98%
Product Type
BIRT 377
Molecular Weight (g/mol)
442.13
Inhibitors
BIRT 377
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Description
- Potent negative allosteric modulator of LFA-1 (lymphocyte function-associated antigen-1) (Kd = 26 nM)
- Binds to the I-domain of LFA-1
- Reversibly inhibits LFA-1 mediated binding of SKW3 leukemia cells to ICAM-1
- Inhibits superantigen (SEB)-induced IL-2 production from lymphocytes in vitro and attenuates the SEB-induced increase in IL-2 plasma levels in a mouse model in vivo
- Orally available.
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Purity: >98%
Product Type: BIRT 377
Molecular Weight (g/mol): 442.13
Inhibitors: BIRT 377
Purity:
>98%
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BIRT 377
Molecular Weight (g/mol):
442.13
Inhibitors:
BIRT 377
Purity: >98%
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Molecular Weight (g/mol): 448.51
Inhibitors: BMS 195614
Purity:
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Product Type:
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Molecular Weight (g/mol):
448.51
Inhibitors:
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Purity: >98%
Product Type: BMS 309403
Molecular Weight (g/mol): 474.55
Inhibitors: BMS 309403
Purity:
>98%
Product Type:
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Molecular Weight (g/mol):
474.55
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Purity: >98%
Product Type: BVT 948
Molecular Weight (g/mol): 241.25
Inhibitors: BVT 948
Purity:
>98%
Product Type:
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Molecular Weight (g/mol):
241.25
Inhibitors:
BVT 948