5545832

Tocris Bioscience™ Indiplon

Positive allosteric modulator of GABAA; acts at benzodiazepine site

Manufacturer: Fischer Scientific

The price for this product is unavailable. Please request a quote

Purity

>99%

Product Type

Indiplon

Molecular Weight (g/mol)

376.43

Inhibitors

Indiplon

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Description

  • Potent GABAA receptor positive allosteric modulator that acts at the benzodiazepine site (Ki values are 1.2 and 1.7 nM in rat frontal cortex and cerebellum respectively)
  • Displays ∽ 10-fold selectivity for α1 subunit-containing receptors (EC50 values are 2.6, 24, 60 and 77 nM for α1β2γ2, α2β2γ2, α3β3γ2 and α5β2γ2 receptors respectively)
  • Exhibits sedative, hypnotic, anxiolytic and anticonvulsant activity in vivo and is orally active.

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