5545890

Tocris Bioscience™ ML 347

Potent and selective ALK1 and ALK2 inhibitor

Manufacturer: Fischer Scientific

The price for this product is unavailable. Please request a quote

Purity

>98%

Product Type

ML 347

Inhibitors

ML 347

Gene Alias

LDN 193719, 1 lWY, VU0469381

Molecular Weight (g/mol)

352.39

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Description

  • Potent and selective ALK2 and ALK1 inhibitor (IC50 values are 32 and 46 nM, respectively); displays >200 fold selectivity over ALK3 and ALK6 and >400 fold selectivity over VEGF2
  • Exhibits no activity at ALK4, ALK5 or in a panel of related kinases
  • Inhibits BMP4 signaling in a functional assay (IC50 = 152 nM).

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