Potent and selective ALK2 and ALK1 inhibitor (IC50 values are 32 and 46 nM, respectively); displays >200 fold selectivity over ALK3 and ALK6 and >400 fold selectivity over VEGF2
Exhibits no activity at ALK4, ALK5 or in a panel of related kinases
Inhibits BMP4 signaling in a functional assay (IC50 = 152 nM).